Does XIST safeguard against sex-biased human diseases?

被引：1
作者：
Sado, Takashi [1 ,2 ]
机构：
[1] Kindai Univ, Grad Sch Agr, Dept Adv Biosci, Nara 6318505, Japan
[2] Kindai Univ, Agr Technol & Innovat Res Inst, Nara 6318505, Japan
来源：
MOLECULAR CELL | 2021年 / 81卷 / 08期
关键词：
X-CHROMOSOME; RNA;
D O I：
10.1016/j.molcel.2021.03.036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Yu et al. (2021) demonstrate that a subset of X-linked immune genes is repressed on the inactive X chromosome (Xi) in a manner dependent on XIST RNA in B cells, and derepression of these genes upon XIST depletion could bias differentiation of naive B cells and be involved in etiology of female-biased autoimmune diseases.
引用
收藏
页码：1598 / 1600
页数：3
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