A heavy-atom-free π-extended N-confused porphyrin as a photosensitizer for photodynamic therapy

被引：15

作者：

Babu, Balaji ^{[1
]}

Mack, John ^{[1
]}

Nyokong, Tebello ^{[1
]}

机构：

[1] Rhodes Univ, Inst Nanotechnol Innovat, Dept Chem, Makhanda, South Africa

来源：

NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

MAGNETIC CIRCULAR-DICHROISM; GREEN LIGHT; DYES; ISOMER; RED;

D O I：

10.1039/d1nj00112d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and characterization of a novel 1,3-diethyl-2-thiobarbituric-acid-substituted N-confused porphyrin (NCP-TB) is reported, along with a study of its photodynamic activity against MCF-7 cells using 530 (110 mW cm(-2)) and 660 nm (280 mW cm(-2)) Thorlabs light-emitting diodes for 30 min. The singlet oxygen quantum yield for NCP-TB is 0.38 compared to 0.23 for the parent unsubstituted N-confused porphyrin (NCP) due to the presence of a sulfur atom. NCP-TB exhibits enhanced PDT activity compared to NCP at both wavelengths. A significantly lower IC50 value of 5.2 mu M was obtained at 530 nm (14.7 mu M at 660 nm) despite a smaller light dose, due to a large red shift of the intense B band into the green region of the spectrum. 2 ',7 '-Dichlorofluorescein diacetate (DCFDA) assays demonstrate that there is intracellular generation of reactive oxygen species upon exposure to light.

引用

页码：5654 / 5658

页数：5

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