A comparative trial of three therapeutic regimens: ciprofloxacin-rifampin, ciprofloxacin-doxycycline and doxycycline-rifampin in the treatment of brucellosis

被引：23

作者：

Keramat, Fariba ^{[1
]}

Ranjbar, Mitra ^{[3
]}

Mamani, Mojgan ^{[1
]}

Hashemi, Seyyed Hamid ^{[1
]}

Zeraati, Fatemeh ^{[2
]}

机构：

[1] Hamedan Univ Med Sci, Dept Infect Dis, Hamadan, Iran

[2] Hamedan Univ Med Sci, Dept Pharmacol, Hamadan, Iran

[3] Iran Univ Med Sci, Dept Infect Dis, Tehran, Iran

来源：

TROPICAL DOCTOR | 2009年 / 39卷 / 04期

关键词：

CLINICAL-MANIFESTATIONS; QUINOLONES;

D O I：

10.1258/td.2009.090030

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This study was designed to compare the efficacy of ciprofloxacin plus rifampin (CR) and ciprofloxacin plus doxycycline (CD) versus doxycycline plus rifampin (DR) in the treatment of brucellosis. A total of 178 patients with brucellosis who were referred to the Sina Hospital, Hamedan, Iran, were included. The responses to therapy were observed in 166 cases (93.7%) - 59 were in the DR group, 59 in the CR group and 48 in the CD group. No significant differences in the therapeutic responses were observed (P = 0.09). Relapse was observed in 11.7% (DR 7.7%, CR 8.3% and CD 17.5%) after a six-month follow-up. No significant differences were also observed in relapse rates among the three groups (P = 0.35). We concluded that DR is still the first choice regimen and CR or CD may be used as alternatives for treatment of brucellosis in adults.

引用

页码：207 / 210

页数：4

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