Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs

被引：39

作者：

Huo, Congde ^{[3
]}

Yang, Huanjie ^{[1
,2
]}

Cui, Qiuzhi Cindy ^{[1
,2
]}

Dou, Q. Ping ^{[1
,2
]}

Chan, Tak Hang ^{[3
,4
]}

机构：

[1] Wayne State Univ, Barbara Ann Karmanos Canc Inst, Prevent Program, Detroit, MI 48202 USA

[2] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 USA

[3] McGill Univ, Dept Chem, Montreal, PQ, Canada

[4] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ENANTIOSELECTIVE SYNTHESIS; PROSTATE-CANCER; IN-VITRO; METHYLATION; APOPTOSIS; PRODRUG; GROWTH; (-)-EPIGALLOCATECHIN-3-GALLATE; PHARMACOGENETICS; INDUCTION;

D O I：

10.1016/j.bmc.2009.12.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A pro-drug 8 of a synthetic analog 7 is more active in its antiproliferative activity against human breast cancer MDA-MB-231 cells possessing high catechol-O-methyltransferase (COMT) activity than the prodrugs of EGCG and the analog 5. The higher activity of 8 is attributed to it not being a substrate of COMT. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1252 / 1258

页数：7

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