Stratum Corneum Damage and ex vivo Porcine Skin Water Absorption - A Pilot Study

被引：4

作者：

Lynggaard, C. Duch ^{[1
]}

Knudsen, D. Bang ^{[2
]}

Jemec, G. B. E. ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Dermatol, Roskilde Hosp, Fac Hlth Sci, DK-4000 Roskilde, Denmark

[2] Coloplast Res, Coloplast, Humlebaek, Denmark

来源：

SKIN PHARMACOLOGY AND PHYSIOLOGY | 2009年 / 22卷 / 06期

关键词：

Porcine skin; Water absorption barrier damage; Skin irritants; IN-VITRO; EAR SKIN; BARRIER FUNCTION; MODEL;

D O I：

10.1159/000241298

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：295 / 298

页数：4

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