Targeting Abnormal Hematopoietic Stem Cells in Chronic Myeloid Leukemia and Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms

被引：9
作者：
Yung, Yammy [1 ]
Lee, Emily [1 ]
Chu, Hiu-Tung [1 ]
Yip, Pui-Kwan [1 ]
Gill, Harinder [1 ]
机构：
[1] Univ Hong Kong, LKS Fac Med, Dept Med, Div Haematol Med Oncol & Haemopoiet Stem Cell Tra, Hong Kong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 02期
关键词：
stem cells; chronic myeloid leukemia; myeloproliferative neoplasm; targeted therapy; TYROSINE KINASE INHIBITORS; BONE-MARROW MICROENVIRONMENT; MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION; HISTONE DEACETYLASE INHIBITORS; HYPOXIA-INDUCIBLE FACTORS; PHASE-II TRIAL; INTERFERON-ALPHA; OPEN-LABEL; TELOMERASE INHIBITOR; POLYCYTHEMIA-VERA;
D O I：
10.3390/ijms22020659
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Myeloproliferative neoplasms (MPNs) are unique hematopoietic stem cell disorders sharing mutations that constitutively activate the signal-transduction pathways involved in haematopoiesis. They are characterized by stem cell-derived clonal myeloproliferation. The key MPNs comprise chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). CML is defined by the presence of the Philadelphia (Ph) chromosome and BCR-ABL1 fusion gene. Despite effective cytoreductive agents and targeted therapy, complete CML/MPN stem cell eradication is rarely achieved. In this review article, we discuss the novel agents and combination therapy that can potentially abnormal hematopoietic stem cells in CML and MPNs and the CML/MPN stem cell-sustaining bone marrow microenvironment.
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页码：1 / 43
页数：39
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