COVID-19: Physiopathology and Targets for Therapeutic Intervention

被引：5

作者：

de Almeida, Juliana O. ^{[1
]}

de Oliveira, Victoria Regina T. ^{[1
]}

Avelar, Joao Lucas dos S. ^{[1
]}

Moita, Bruna Simoes ^{[1
]}

Lima, Lidia Moreira ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Lab Avaliacao & Sintese Subst Bioat, Av Pedro Calmon 550,CP 68024,Cidade Univ, BR-21941902 Rio De Janeiro, RJ, Brazil

来源：

REVISTA VIRTUAL DE QUIMICA | 2020年 / 12卷 / 06期

关键词：

COVID-19; SARS-CoV-2; molecular targets; spike protein; proteases; PAPAIN-LIKE PROTEASES; DROMEDARY CAMELS; SPIKE PROTEIN; SARS-COV; CORONAVIRUS; DRUG; INFECTION; SYSTEM; ACE2; IDENTIFICATION;

D O I：

10.21577/1984-6835.20200115

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pandemic status of COVID-19 was recorded by the World Health Organization (WHO) on March 11, 2020. Since then, more than 10 million cases have been confirmed worldwide, with more than 500,000 reported deaths. Throughout this period, efforts by the global scientific community have focused on understanding the disease process and searching on preventive (e.g. vaccines) or therapeutic (e.g. drugs) alternatives of treatment for COVID-19. The present review portrays the historical aspects associated with the discovery of SARS-CoV-2, the etiological agent of COVID-19, describes the pathophysiological aspects of the disease, the viral replication process and discusses the main molecular targets subject to therapeutic intervention, aiming the design, discovery and development of new drugs to treat COVID-19.

引用

页码：1464 / 1497

页数：34

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