Cellular Efflux of cAMP and cGMP - A Question about Selectivity

被引：39

作者：

Sager, Georg ^{[1
]}

Ravna, Aina Westrheim ^{[1
]}

机构：

[1] Univ Tromso, Fac Med, Dept Pharmacol, Inst Med Biol, N-9037 Tromso, Norway

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 08期

关键词：

cGMP; cAMP; ABCC4; ABCC5; ABCC11; transport selectivity; GUANOSINE; 3'; 5'-CYCLIC-MONOPHOSPHATE CGMP; MULTIDRUG-RESISTANCE PROTEIN-4; INSIDE-OUT VESICLES; RAT GLIOMA-CELLS; CYCLIC-AMP; HUMAN ERYTHROCYTES; ADENOSINE 3,5-MONOPHOSPHATE; TRANSPORTER SUPERFAMILY; STRUCTURAL BASIS; ATPASE ACTIVITY;

D O I：

10.2174/138955709788681654

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5 (MRP5) and ABCC11 (MRP8) as cellular efflux pumps for cAMP and cGMP. These transporters are potential drug targets for selective modulation of cyclic nucleotide action.

引用

页码：1009 / 1013

页数：5

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