Soluble CD40 ligand contributes to blood-brain barrier breakdown and central nervous system inflammation in multiple sclerosis and neuromyelitis optica spectrum disorder

被引：44

作者：

Masuda, Hiroki ^{[1
]}

Mori, Masahiro ^{[1
]}

Uchida, Tomohiko ^{[1
]}

Uzawa, Akiyuki ^{[1
]}

Ohtani, Ryohei ^{[1
]}

Kuwabara, Satoshi ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Neurol, 1-8-1 Inohana, Chiba, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 305卷

关键词：

Blood-brain barrier; Central nervous system; Cerebrospinal fluid; Multiple sclerosis; Neuromyelitis optica; CD40; ligand; CEREBROSPINAL-FLUID; LUPUS-ERYTHEMATOSUS; T-CELLS; INTERLEUKIN-17; PRODUCTION; DIAGNOSTIC-CRITERIA; ELEVATED LEVELS; DISEASE; PROTEIN; ANTIBODIES; RESPONSES;

D O I：

10.1016/j.jneuroim.2017.01.024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Soluble CD40 ligand (sCD4OL) is reported to disrupt the blood-brain barrier (BBB). Cerebrospinal fluid (CSF) and serum sCD4OL levels were measured in 29 multiple sclerosis (MS), 29 neuromyelitis optica spectrum disorder (NMOSD), and 27 disease control (DC) patients. In MS, serum sCD4OL levels were higher than in DCs and positively correlated with the CSF/serum albumin ratio (Qalb). In NMOSD, CSF sCD4OL levels were significantly increased compared to DCs, and were correlated to Qalb, CSF cell counts, protein concentrations, and interleukin-6 levels. sCD4OL could be involved in BBB disruption in MS, whereas it may contribute to CNS inflammation in NMOSD. (C) 2017 Elsevier B.V. All rights reserved.

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页码：102 / 107

页数：6

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