Polymorphism in Cytochrome P4501A1 is Significantly Associated with Head and Neck Cancer Risk

被引：27

作者：

Singh, Arvind P. ^{[1
]}

Shah, Parag P. ^{[1
]}

Ruwali, Munindra ^{[1
]}

Mathur, Neeraj ^{[2
]}

Pant, Mohan C. ^{[3
]}

Parmar, Devendra ^{[1
]}

机构：

[1] Indian Inst Toxicol Res, Div Dev Toxicol, CSIR, Lucknow, Uttar Pradesh, India

[2] Indian Inst Toxicol Res, Environm Epidemiol Div, CSIR, Lucknow, Uttar Pradesh, India

[3] Chhatrapti Shahuji Maharaj Med Univ, Dept Radiotherapy, Lucknow, Uttar Pradesh, India

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 08期

关键词：

Head and neck cancer; Cytochrome P450 1A1; Polymorphism; Haplotypes; Risk; SQUAMOUS-CELL CARCINOMA; DRUG-METABOLIZING-ENZYMES; GENETIC POLYMORPHISMS; LUNG-CANCER; ORAL-CANCER; CYP1A1; POLYMORPHISMS; HIGH SUSCEPTIBILITY; COMBINED GENOTYPES; CIGARETTE-SMOKING; POOLED ANALYSIS;

D O I：

10.1080/07357900902849657

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The HNSCC risk also increased several folds in cases with combination of variant genotypes of CYP1A1*2A or CYP1A1*2C with null genotype of glutathione-S-transferase M1 (GSTM1), a phase II enzyme, particularly in cases who were tobacco users (smokers and tobacco chewers), demonstrating the role of gene-gene and gene-environment interactions in the development of HNSCC.

引用

页码：869 / 876

页数：8

共 51 条

[1] Cytochrome P450 gene polymorphism and cancer
Agúndez, JAG
[J]. CURRENT DRUG METABOLISM, 2004, 5 (03) : 211 - 224
[2] Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians:: tobacco exposure as a risk modulator
Anantharaman, Devasena
Chaubal, Pranay M.
Kannan, Sadhana
Bhisey, Rajani A.
Mahimkar, Manoj B.
[J]. CARCINOGENESIS, 2007, 28 (07) : 1455 - 1462
[3] [Anonymous], 1985, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, V37, P37
[4] A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms
Arand, M
Muhlbauer, R
Hengstler, J
Jager, E
Fuchs, J
Winkler, L
Oesch, F
[J]. ANALYTICAL BIOCHEMISTRY, 1996, 236 (01) : 184 - 186
[5] Bartsch H, 2000, CANCER EPIDEM BIOMAR, V9, P3
[6] Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population
Buch, SC
Notani, PN
Bhisey, RA
[J]. CARCINOGENESIS, 2002, 23 (05) : 803 - 807
[7] Cascorbi I, 1996, CANCER RES, V56, P4965
[8] Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer
Cha, In-Ho
Park, Jong Yun
Chung, Won-Yoon
Choi, Min-Ah
Kim, Hyung-Jun
Park, Kwang-Kyun
[J]. YONSEI MEDICAL JOURNAL, 2007, 48 (02) : 233 - 239
[9] Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk
Chang, BL
Zheng, SL
Isaacs, SD
Turner, A
Hawkins, GA
Wiley, KE
Bleecker, ER
Walsh, PC
Meyers, DA
Isaacs, WB
Xu, JF
[J]. INTERNATIONAL JOURNAL OF CANCER, 2003, 106 (03) : 375 - 378
[10] Cheng L, 1999, INT J CANCER, V84, P220, DOI 10.1002/(SICI)1097-0215(19990621)84:3<220::AID-IJC4>3.0.CO

← 1 2 3 4 5 6 →