Effects of intracoronary low-dose prourokinase administration on ST-segment elevation in patients with myocardial infarction and a high thrombus burden: a randomized controlled trial

被引：5

作者：

Cao, Mingkun ^{[1
]}

Wang, Zhiyong ^{[2
]}

Meng, Xiujie ^{[3
]}

Xu, Zhiru ^{[2
]}

Gao, Jiangfeng ^{[2
]}

Zhu, Wangliang ^{[2
]}

Yu, Suhua ^{[4
]}

Zhang, Haijun ^{[5
]}

机构：

[1] Natl United Engn Lab Biomed Mat Modificat, Dezhou, Peoples R China

[2] Inner Mongolia Peoples Hosp, Internal Med Cardiovasc Dept, Hohhot, Inner Mongolia, Peoples R China

[3] Inner Mongolia Int Mongolian Med Hosp, Internal Med Cardiovasc Dept, Hohhot, Inner Mongolia, Peoples R China

[4] Blue Sail Pioneer Lab, JW Med Syst, Jiwei, Shandong, Peoples R China

[5] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, 301 Yanvhang Rd, Shanghai 200092, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2022年 / 50卷 / 12期

关键词：

Low-dose prourokinase; ST-elevation myocardial infarction; percutaneous coronary intervention; high thrombus burden; myocardial reperfusion; cardiac function; cardiac perfusion; PERCUTANEOUS CORONARY INTERVENTION; STREPTOKINASE; THROMBECTOMY; ASPIRATION; SARUPLASE; ALTEPLASE; FLOW;

D O I：

10.1177/03000605221139723

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: To evaluate the efficacy and safety of low-dose prourokinase (pro-UK) administration during primary percutaneous coronary intervention (PCI) for the treatment of acute ST-segment elevation myocardial infarction (STEMI) in patients with a high thrombus burden. Methods: A prospective, randomized controlled trial was conducted at the Inner Mongolia People's Hospital, China. Patients with STEMI and a high thrombus burden who underwent thrombus aspiration and primary PCI were randomly allocated to pro-UK administration or control groups. The primary endpoint was corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC). Results: There were no significant differences in the baseline demographics or clinical characteristics of the two groups. The CTFC, tissue myocardial perfusion grade, ST-segment resolution, and myocardial blush grade of the pro-UK group were significantly better than those of the control group. In addition, after 30 days of follow-up, the pro-UK group had better cardiac function and perfusion than the control group. There were no differences in the clinical outcomes or incidence of hemorrhage. Conclusions: Intracoronary low-dose pro-UK improves myocardial perfusion and cardiac function in patients with a high thrombus burden. Major hemorrhages still occur in patients administered pro-UK, but are no more frequent. Study registration: Chinese Clinical Trial Registry (ChiCTR1900022290).

引用

页数：12

共 33 条

[1] Efficacy and Safety of a Pharmaco-Invasive Strategy With Half-Dose Alteplase Versus Primary Angioplasty in ST-Segment-Elevation Myocardial Infarction: EARLY-MYO Trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute ST-Segment-Elevation Myocardial Infarction) (vol 136, pg 1462, 2017) [J].

Pu .

CIRCULATION, 2018, 137 (07) :E29-E29

[2] Absence of a correlation between the ABO blood group and thrombus burden in patients with ST-segment elevation myocardial infarction [J].

Askin, Lutfu ;

Cetin, Mustafa ;

Turkmen, Serdar .

CORONARY ARTERY DISEASE, 2018, 29 (02) :145-150

[3]

Bar FW, 1997, AM J CARDIOL, V79, P727

[4]

Bell William R, 2002, Rev Cardiovasc Med, V3 Suppl 2, pS34

[5] ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction - Insights from the Assessment of PEXelizumab in Acute Myocardial Infarction (APEX-AMI) trial [J].

Buller, Christopher E. ;

Fu, Yuling ;

Mahaffey, Kenneth W. ;

Todaro, Thomas G. ;

Adams, Peter ;

Westerhout, Cynthia M. ;

White, Harvey D. ;

Hof, Arnoud W. J. Van 't ;

De Werf, Frans J. Van ;

Wagner, Galen S. ;

Granger, Christopher B. ;

Armstrong, Paul W. .

CIRCULATION, 2008, 118 (13) :1335-1346

[6] Comparison of myocardial microcirculatory perfusion after catheter-administered intracoronary thrombolysis with anisodamine versus standard thrombus aspiration in patients with ST-elevation myocardial infarction [J].

Fu, Yang ;

Gu, Xin-Shun ;

Hao, Guo-Zhen ;

Jiang, Yun-Fa ;

Fan, Wei-Ze ;

Fan, Yan-Ming ;

Wei, Qing-Min ;

Fu, Xiang-Hua ;

Li, Yong-Jun .

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2019, 93 :839-845

[7] Aspiration thrombectomy and intracoronary tirofiban in ST-segment elevationmyocardial infarction Combination treatment for patients undergoing primary percutaneous coronary intervention [J].

Geng, T. ;

Zhang, J. -G. ;

Song, Z. -Y. ;

Dai, S. -P. ;

Luo, Y. ;

Xu, Z. -S. .

HERZ, 2016, 41 (08) :732-739

[8] A randomized study of prourokinase during primary percutaneous coronary intervention in acute ST-segment elevation myocardial infarction [J].

Geng, Wei ;

Zhang, Qi ;

Liu, Jingmin ;

Tian, Xiang ;

Zhen, Libo ;

Song, Da ;

Yang, Ying ;

Meng, Haiyun ;

Wang, Yafang ;

Chen, Jianjun .

JOURNAL OF INTERVENTIONAL CARDIOLOGY, 2018, 31 (02) :136-143

[9] Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs [J].

Gibson, CM ;

Cannon, CP ;

Murphy, SA ;

Ryan, KA ;

Mesley, R ;

Marble, SJ ;

McCabe, CH ;

Van de Werf, F ;

Braunwald, E .

CIRCULATION, 2000, 101 (02) :125-130

[10] Relationship between TIMI frame count and clinical outcomes after thrombolytic administration [J].

Gibson, CM ;

Murphy, SA ;

Rizzo, MJ ;

Ryan, KA ;

Marble, SJ ;

McCabe, CH ;

Cannon, CP ;

Van de Werf, F ;

Braunwald, E .

CIRCULATION, 1999, 99 (15) :1945-1950

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