Use of prothrombin complex concentrates for urgent reversal of dabigatran in the Emergency Department

被引:38
作者
Quintana Diaz, Manuel [1 ,2 ]
Borobia, Alberto M. [1 ,3 ]
Rivera Nunez, Ma Angelica [1 ]
Martinez Virto, Ana Maria [1 ]
Fabra, Sara [1 ]
Sanchez Casado, Marcelino [4 ]
Garcia-Erce, Jose A. [5 ]
Meyer Samama, C. [5 ]
机构
[1] Hosp Univ La Paz Madrid, Gen Emergency Dept, IdiPAZ, Madrid, Spain
[2] Hosp Univ La Paz Madrid, IdiPAZ, Intens Care Unit, Madrid, Spain
[3] Univ Autonoma Madrid, Hosp Univ La Paz Madrid, Sch Med, Clin Pharmacol Serv,IdiPAZ, E-28049 Madrid, Spain
[4] Hosp Virgen Salud, Intens Care Unit, Toledo, Spain
[5] Hosp San Jorge Huesca, Haematol Serv, Huesca, Spain
关键词
dabigatran; prothrombin complex concentrate; bleeding; reversal; ATRIAL-FIBRILLATION; ETEXILATE; RIVAROXABAN; ENOXAPARIN; WARFARIN;
D O I
10.3324/haematol.2013.092767
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E143 / E144
页数:2
相关论文
共 13 条
  • [1] [Anonymous], PRAD MON
  • [2] Rivaroxaban versus enoxaparin for thromboprophylaxis after total hip or knee arthroplasty: a meta-analysis of randomized controlled trials
    Cao, Yong Bing
    Zhang, Jun Dong
    Shen, Hui
    Jiang, Yuan Ying
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2010, 66 (11) : 1099 - 1108
  • [3] Switching from enoxaparin to dabigatran etexilate: pharmacokinetics, pharmacodynamics, and safety profile
    Clemens, Andreas
    van Ryn, Joanne
    Sennewald, Regina
    Yamamura, Norio
    Stangier, Joachim
    Feuring, Martin
    Haertter, Sebastian
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 68 (05) : 607 - 616
  • [4] Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate A Randomized, Placebo-Controlled, Crossover Study in Healthy Subjects
    Eerenberg, Elise S.
    Kamphuisen, Pieter W.
    Sijpkens, Meertien K.
    Meijers, Joost C.
    Buller, Harry R.
    Levi, Marcel
    [J]. CIRCULATION, 2011, 124 (14) : 1573 - 1579
  • [5] European Medicines Agency, PRAD DAB ET
  • [6] Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation
    Kansal, Anuraag R.
    Sorensen, Sonja V.
    Gani, Ray
    Robinson, Paul
    Pan, Feng
    Plumb, Jonathan M.
    Cowie, Martin R.
    [J]. HEART, 2012, 98 (07) : 573 - 578
  • [7] Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate
    Lambourne, M. D.
    Eltringham-Smith, L. J.
    Gataiance, S.
    Arnold, D. M.
    Crowther, M. A.
    Sheffield, W. P.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2012, 10 (09) : 1830 - 1840
  • [8] Life-threatening bleeding in four patients with an unusual excessive response to dabigatran: Implications for emergency surgery and resuscitation
    Louet, Agnes Lillo-Le
    Wolf, Martine
    Soufir, Lilia
    Galbois, Arnaud
    Dumenil, Anne-Sylvie
    Offenstadt, Georges
    Samama, Meyer-Michel
    [J]. THROMBOSIS AND HAEMOSTASIS, 2012, 108 (03) : 583 - 585
  • [9] A Novel User-Friendly Score (HAS-BLED) To Assess 1-Year Risk of Major Bleeding in Patients With Atrial Fibrillation The Euro Head Survey
    Pisters, Ron
    Lane, Deirdre A.
    Nieuwlaat, Robby
    de Vos, Cees B.
    Crijns, Harry J. G. M.
    Lip, Gregory Y. H.
    [J]. CHEST, 2010, 138 (05) : 1093 - 1100
  • [10] Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model
    Pragst, I.
    Zeitler, S. H.
    Doerr, B.
    Kaspereit, F. J.
    Herzog, E.
    Dickneite, G.
    Van Ryn, J.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2012, 10 (09) : 1841 - 1848