Synthesis and conformational study of 1,2,3,4,5,6,7,8-octahydro-1,6-naphthiridines

被引：1

作者：

Esipova, T. V. ^{[1
]}

Borisenko, A. A.

Terent'ev, P. B.

Grishina, G. V.

Herzshuh, R.

机构：

[1] Moscow MV Lomonosov State Univ, Moscow 119992, Russia

[2] Univ Leipzig, Leipzig, Germany

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 42卷 / 05期

关键词：

Enamine; Intramolecular Cyclization; Oily Substance; Matrine; Conformational Study;

D O I：

10.1134/S1070428006050162

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new class of endocyclic enamines, 1,6-disubstituted 1,2,3,4,5,6,7,8-octahydro-1,6-naphthiridines, was synthesized from 4-piperidone imines by successive subjecting the latter to lithiation with lithium diethylamide, to alkylation with 1-bromo-3-chloropropane, and to intramolecular cyclization. All stages were carried out as a unique process without isolation of the intermediate compounds. A thorough optimization of the process conditions, workup, and product storage was carried out. The conformational study of 1,6-disubstituted 1,2,3,4,5,6,7,8-octahydro-1,6-naphthiridines was performed.

引用

页码：742 / 747

页数：6

共 50 条

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