Polymorphisms of glutathione S-transferases M1 and T1 do not account for interindividual differences for smoking behavior

To identify whether the polymorphisms of glutathione S-transferase Ml (GSTMl) and GSTTl genes predict a high-tended risk of using tobacco, the GSTMl and GSTTl genotypes of 369 Iranian males (254 nonsmokers and 115 smokers) and 314 Iranian females (245 nonsmokers and 69 smokers) were determined. The frequencies of GSTMl (males: OR=0.98, 95% CI=0.62-1.57, P=.974; females: OR= 1.34, 95% CI=0.75-2.39,P=.358) and GSTTl (males: OR=1.25, 95% CI=0.76-2.04,P=.412; females: OR=0.84, 95% CI-0.46-1.51 P=.626) null genotypes were similar in nonsmokers and smokers. The risk of being a smoker was to be equally frequent in each combination of the genotypes. The present results revealed that there was no difference between smokers and nonsmokers for these two Genetic polymorphisms. (C) 2004 Elsevier Inc. All rights reserved.