EXPRESSION OF GELATINASES (MMP-2, MMP-9) IN HUMAN ARTICULAR CARTILAGE

被引：47

作者：

Lipari, L. ^{[1
]}

Gerbino, A. ^{[1
]}

机构：

[1] Univ Palermo, Dept Expt Biomed & Clin Neurosci, Sect Histol & Embryol, Palermo, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2013年 / 26卷 / 03期

关键词：

articular cartilage; metalloproteinases; immunohistochemistry; osteoarthritis; HUMAN OSTEOARTHRITIC CARTILAGE; MATRIX-METALLOPROTEINASE; II COLLAGEN; GENE-EXPRESSION; CHONDROCYTES; DEGRADATION; CLEAVAGE; INHIBITION; NASAL;

D O I：

10.1177/039463201302600331

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Osteoarthritis (OA) is a chronic degenerative joint disorder. characterized by destruction of the articular cartilage, subchondral bone alterations and synovitis. Matrix metalloproteinases (MMPs) are expressed in joint tissues of patients with osteoarthritis (OA). The objective of this study was to define the steady state levels of two different MMPs to provide more insight into the role of MMPs in cartilage destruction in OA. We investigated the expression of gelatinases through immunohistochemistry Our results show that high levels of MMP-2 and MMP-9 are present in OA and suggest that once these MMPs are fully activated they may contribute to the cartilage destruction in OA.

引用

页码：817 / 823

页数：7

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