Transbilayer movement of phospholipids in biogenic membranes

被引：90

作者：

Kol, MA ^{[1
]}

de Kroon, AIPM ^{[1
]}

Killian, JA ^{[1
]}

de Kruijff, B ^{[1
]}

机构：

[1] Univ Utrecht, Dept Membrane Biochem, Ctr Biomembranes & Lipid Enzymol, Biomembrane Inst, NL-3584 CH Utrecht, Netherlands

来源：

BIOCHEMISTRY | 2004年 / 43卷 / 10期

关键词：

D O I：

10.1021/bi036200f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biogenic membranes contain the enzymes that synthesize the cell's membrane lipids, of which the phospholipids are the most widespread throughout nature. Being synthesized at and inserted into the cytoplasmic leaflet of biogenic membranes, the phospholipids must migrate to the opposite leaflet to ensure balanced growth of the membrane. In this review, the current knowledge of transbilayer movement of phospholipids in biogenic membranes is summarized and the available data are compared to what is known about lipid translocation in other membranes. On the basis of this, a mechanism is proposed, in which phospholipid translocation in biogenic membranes is mediated via membrane-spanning segments of a subset of proteins, characterized by a small number of transmembrane helices. We speculate that proteins of this subset facilitate lipid translocation via the protein-lipid interface, because they display more dynamic behavior and engage in less stable protein-lipid interactions than larger membrane proteins.

引用

页码：2673 / 2681

页数：9

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