CD133 positive cells isolated from A549 cell line exhibited high liver metastatic potential

被引：19

作者：

Zhang, H. ^{[1
,2
]}

Yang, N. ^{[1
,2
]}

Sun, B. ^{[1
,2
]}

Jiang, Y. ^{[1
,2
]}

Hou, C. ^{[1
,2
]}

Ji, C. ^{[1
,2
]}

Zhang, Y. ^{[2
,3
]}

Liu, Y. ^{[1
,2
]}

Zuo, P. ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pharmacol, Beijing 100005, Peoples R China

[2] Peking Union Med Coll, Beijing 100005, Peoples R China

[3] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pathol, Beijing 100005, Peoples R China

来源：

NEOPLASMA | 2014年 / 61卷 / 02期

关键词：

human lung adenocarcinoma; liver metastasis; migration; invasion; CD133; HUMAN LUNG-CANCER; HORMONE-RELATED PROTEIN; ENDOTHELIAL GROWTH-FACTOR; TUMOR-INITIATING CELLS; BONE METASTASIS; STEM-CELLS; NUDE-MICE; IN-VIVO; IDENTIFICATION; MODEL;

D O I：

10.4149/neo_2014_021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapy. In present study, we identified a subpopulation of cells isolated from the A549 cell line with marker CD 133. In vivo results showed that A549 CD133(+) cells displayed high liver metastatic potential. Severe liver cell damage with tumor cell invasion revealed by pathological examination and these changes were consistent with the results of serological tests where the plasma GPT and GOT level are significantly higher than that of the control group. Compared with A549 cells, A549 CD133(+) cells expressed high levels of VEGF and exhibited high migration and invasion capability. In conclusion, we first reported that A549 CD133(+) cells exhibited characteristic of high liver metastatic potential which makes it be a suitable model for further study of liver metastasis of lung adenocarcinoma and provide a potential platform for anti-metastatic drug discovery or evaluation.

引用

页码：153 / 160

页数：8

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