TGF-β antagonists:: Why suppress a tumor suppressor?

被引:107
作者
Akhurst, RJ [1 ]
机构
[1] Univ Calif San Francisco, Mt Zion Canc Res Inst, San Francisco, CA 94143 USA
关键词
D O I
10.1172/JCI200215970
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:1533 / 1536
页数:4
相关论文
共 20 条
[1]   TGF-β signaling in cancer -: a double-edged sword [J].
Akhurst, RJ ;
Derynck, R .
TRENDS IN CELL BIOLOGY, 2001, 11 (11) :S44-S51
[2]  
Bandyopadhyay A, 1999, CANCER RES, V59, P5041
[3]   The ErbB receptor family: a therapeutic target for cancer [J].
de Bono, JS ;
Rowinsky, EK .
TRENDS IN MOLECULAR MEDICINE, 2002, 8 (04) :S19-S26
[4]   TGF-β signaling in tumor suppression and cancer progression [J].
Derynck, R ;
Akhurst, RJ ;
Balmain, A .
NATURE GENETICS, 2001, 29 (02) :117-129
[5]  
Engle SJ, 1999, CANCER RES, V59, P3379
[6]   Cyclosporine induces cancer progression by a cell-autonomous mechanism [J].
Hojo, M ;
Morimoto, T ;
Maluccio, M ;
Asano, T ;
Morimoto, K ;
Lagman, M ;
Shimbo, T ;
Suthanthiran, M .
NATURE, 1999, 397 (6719) :530-534
[7]   Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis:: dissection of Ras signaling pathways [J].
Janda, E ;
Lehmann, K ;
Killisch, I ;
Jechlinger, M ;
Herzig, M ;
Downward, J ;
Beug, H ;
Grünert, S .
JOURNAL OF CELL BIOLOGY, 2002, 156 (02) :299-313
[8]  
KAKONEN SM, 2002, IN PRESS J BIOL CHEM
[9]   Induction of angiogenesis by expression of soluble type II transforming growth factor-β receptor in mouse hepatoma [J].
Kim, KY ;
Jeong, SY ;
Won, J ;
Ryu, PD ;
Nam, MJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :38781-38786
[10]  
MINCIONE G, 1993, CANCER RES, V53, P5548