Identification of a synthetic cannabinoid A-836339 as a novel compound found in a product

被引：11

作者：

Uemura, Nozomi ^{[1
]}

Fukaya, Haruhiko ^{[2
]}

Kanai, Chieko ^{[1
]}

Yoshida, Masao ^{[1
]}

Nakajima, Jun'ichi ^{[1
]}

Takahashi, Misako ^{[1
]}

Suzuki, Jin ^{[1
]}

Moriyasu, Takako ^{[1
]}

Nakae, Dai ^{[1
]}

机构：

[1] Tokyo Metropolitan Inst Publ Hlth, Shinjuku Ku, Tokyo 1690073, Japan

[2] Tokyo Univ Pharm & Life Sci, Instrumental Anal Ctr, Hachioji, Tokyo 19203, Japan

来源：

FORENSIC TOXICOLOGY | 2014年 / 32卷 / 01期

关键词：

A-836339; Synthetic cannabinoid; X-Ray crystallographic analysis; TOF-MS; NMR; DESIGNER DRUGS; DERIVATIVES; FUBINACA; AGONIST; ANALOG; ACID;

D O I：

10.1007/s11419-013-0201-x

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

As a part of the work conducted in our laboratory, we encountered a case in which new chemical compound was contained in a certain product. This compound was found to have a molecular weight of 310 Da by liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. Accurate mass spectrometry measurements showed that the compound had an elemental composition of C16H26N2O2S. Using these mass data together with those obtained by nuclear magnetic resonance analysis and X-ray crystallographic analysis, this compound was identified as N-[3-(2-methoxyethyl)-4,5-dimethyl-2(3H)-thiazolylidene]-2,2,3,3-tetramethylcyclopropanecarboxamide, which was reported in 2009 and named A-836339. It was described as a thiazol derivative and a selective agonist of G-protein-coupled cannabinoid receptor CB2. This is the first report to identify this compound in a dubious product.

引用

页码：45 / 50

页数：6

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