Circular RNAs in cell differentiation and development

被引：39

作者：

Di Timoteo, Gaia ^{[1
]}

Rossi, Francesca ^{[1
]}

Bozzoni, Irene ^{[1
,2
]}

机构：

[1] Sapienza Univ Rome, Dept Biol & Biotechnol Charles Darwin, Rome, Italy

[2] Ist Italiano Tecnol, Ctr Life Nano Sci Sapienza, Rome, Italy

来源：

DEVELOPMENT | 2020年 / 147卷 / 16期

基金：

欧洲研究理事会; 欧盟地平线“2020”;

关键词：

Developmental biology; Differentiation; circRNAs; Noncoding RNAs; Stem cells; MESENCHYMAL STEM-CELLS; ABUNDANT; EXPRESSION; PROMOTES; REVEALS; BRAIN; IDENTIFICATION; TRANSCRIPTION; OSTEOGENESIS; TRANSLATION;

D O I：

10.1242/dev.182725

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In recent years, circular RNAs (circRNAs) - a novel class of RNA molecules characterized by their covalently closed circular structure have emerged as a complex family of eukaryotic transcripts with important biological features. Besides their peculiar structure, which makes them particularly stable molecules, they have attracted much interest because their expression is strongly tissue and cell specific. Moreover, many circRNAs are conserved across eukaryotes, localized in particular subcellular compartments, and can play disparate molecular functions. The discovery of circRNAs has therefore added not only another layer of gene expression regulation but also an additional degree of complexity to our understanding of the structure, function and evolution of eukaryotic genomes. In this Review, we summarize current knowledge of circRNAs and discuss the possible functions of circRNAs in cell differentiation and development.

引用

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