De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression

被引：9

作者：

Igawa, Takuro ^{[1
]}

Sato, Yasuharu ^{[1
]}

Takata, Katsuyoshi ^{[1
]}

Iwaki, Noriko ^{[1
]}

Tanaka, Takehiro ^{[2
]}

Asano, Naoko ^{[3
]}

Maeda, Yoshinobu ^{[4
]}

Orita, Yorihisa ^{[5
]}

Nakamura, Naoya ^{[6
]}

Nakamura, Shigeo ^{[7
]}

Yoshino, Tadashi ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol, Okayama 7008558, Japan

[2] Okayama Univ Hosp, Dept Pathol, Okayama, Japan

[3] Nagoya Univ Hosp, Dept Clin Lab, Nagoya, Aichi, Japan

[4] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol, Okayama 7008558, Japan

[5] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Okayama 7008558, Japan

[6] Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa 25911, Japan

[7] Nagoya Univ Hosp, Dept Pathol, Nagoya, Aichi, Japan

来源：

DIAGNOSTIC PATHOLOGY | 2013年 / 8卷

关键词：

Cyclin D2; CD5; Diffuse large B-cell lymphoma; SURVIVAL; PREDICTS;

D O I：

10.1186/1746-1596-8-81

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

D cyclins positively regulate the cell cycle and mediate the pathogenesis of some lymphomas. Cyclin D1 overexpression is the hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 are reportedly not as specific to certain lymphomas as cyclin D1. In this study, cyclin D2 was found to be overexpressed in 98% of de novo CD5-positive diffuse large B-cell lymphomas (DLBCLs) (50/51) and in 28% of CD5-negative DLBCLs (14/51). A statistically significant difference was observed between these two groups (p<0.0001). In contrast, no statistical difference was found in the cyclin D3 expression between CD5-positive (18/51) and CD5-negative (24/51) DLBCLs (p=0.23). Based on these findings, cyclin D2 is therefore considered to be closely associated with de novo CD5-positive DLBCLs. This insight may be useful for overcoming the inferior survival of this aggressive lymphoma. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1382856320966453

引用

页数：3

共 13 条

[11] SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype (vol 94, pg 1555, 2009) [J].

Mozos, Ana .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 (09) :1620-1620

[12] De novo CD5+ diffuse large B-cell lymphoma:: a clinicopathologic study of 109 patients [J].

Yamaguchi, M ;

Seto, M ;

Okamoto, M ;

Ichinohasama, R ;

Nakamura, N ;

Yoshino, T ;

Suzumiya, J ;

Murase, T ;

Miura, I ;

Akasaka, T ;

Tamaru, J ;

Suzuki, R ;

Kagami, Y ;

Hirano, M ;

Morishima, Y ;

Ueda, R ;

Shiku, H ;

Nakamura, S .

BLOOD, 2002, 99 (03) :815-821

[13]

Yatabe Y, 2000, BLOOD, V95, P2253

← 1 2 →