A Template for New Drugs against Alzheimer's Disease

被引：15
|
作者：
Aguzzi, Adriano [1 ]
Gitler, Aaron D. [2 ]
机构：
[1] Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland
[2] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA
来源：
CELL | 2013年 / 154卷 / 06期
关键词：
TAU INCLUSIONS;
D O I：
10.1016/j.cell.2013.08.049
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) is associated with the deposition of beta-amyloid (A beta) plaques in the brain. In this issue, by cleverly processing patient samples, Lu et al. define a novel structural model of A beta fibrils from AD brain, revealing surprising differences from in vitro fibrils. These findings may lead to structure-specific inhibitors and more selective amyloid-imaging methods.
引用
收藏
页码：1182 / 1184
页数：3
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