Body mass index and the visceral adipose tissue expression of IL-6 and TNF-alpha are associated with the morphological severity of non-alcoholic fatty liver disease in individuals with class III obesity

被引：54

作者：

Barcala Jorge, Antonio Sergio ^{[1
,2
]}

Oliveira Andradea, Joao Marcus ^{[1
]}

Paraiso, Alanna Fernandes ^{[1
]}

Batista Jorge, Gislaine Candida ^{[1
]}

Silveira, Christine Mendes ^{[1
,2
]}

de Souza, Ludmilla Regina ^{[1
]}

Santos, Erivelton Pereira ^{[1
]}

Sena Guimaraes, Andre Luiz ^{[1
,3
]}

Sousa Santos, Sergio Henrique ^{[1
,3
]}

Batista De-Paula, Alfredo Mauricio ^{[1
,4
]}

机构：

[1] Univ Estadual Montes Claros, Nucleus Epidemiol & Mol Res Catrumano, Hlth Res Lab, Hlth Sci Postgrad Programme, BR-39401001 Montes Claros, MG, Brazil

[2] Univ Estadual Montes Claros, Dept Physiopathol, BR-39401001 Montes Claros, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Food Engn, BR-39404547 Montes Claros, MG, Brazil

[4] Univ Estadual Montes Claros, Dept Dent, BR-39401001 Montes Claros, MG, Brazil

来源：

OBESITY RESEARCH & CLINICAL PRACTICE | 2018年 / 12卷 / 01期

关键词：

Class III obesity; Non-alcoholic fatty liver disease; Anthropometric factors; Proinflammatory cytokines; Real-time-PCR; TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; CHINESE PATIENTS; CIRCULATING INTERLEUKIN-6; INFLAMMATION; STEATOHEPATITIS; PATHOGENESIS; CYTOKINES; NAFLD; PROGRESSION;

D O I：

10.1016/j.orcp.2016.03.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To analyze the mRNA expression of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in the liver and white adipose tissue samples of individuals with class III obesity (body mass index >= 40.0 kg/m(2)) with non-alcoholic fatty liver disease (NAFLD).& para;& para;Methods: This cross-sectional study included patients with class III obesity exhibiting early or late morphological presentation of NAFLD (non-alcoholic hepatic steatosis [NAFL], n = 8 and non-alcoholic steatohepatitis [NASH], n=13, respectively). All patients underwent bariatric surgery and peripheral blood, liver, and visceral white adipose tissue (WAT) samples were collected. Socio-demographic, anthropometric, clinical, plasma biochemical, and nutritional characteristics of each study subject were assessed and compared between patients presenting with NAFL and NASH. IL-6 and TNF-alpha mRNA expression in the liver and WAT samples were measured by using quantitative real time-polymerase chain reaction (qRT-PCR).& para;& para;Results: Individuals with class III obesity and NASH showed higher body mass index (BMI) and higher IL-6 and TNF-alpha mRNA expression in the WAT compared to that of patients with NAFL (p = 0.01, for all associations).& para;& para;Conclusions: Individuals with class III obesity with higher morphological severity of NAFLD exhibited higher BMI and higher IL-6 and TNF-alpha expression in the WAT. Future prospective studies are warranted to determine how BMI, IL-6, and TNF-alpha affect the progression of NAFLD in individuals with class III obesity. (C) 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

引用

页码：1 / 8

页数：8

共 69 条

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