Psychotropic Drug Treatment in Anorexia Nervosa. Search for Differences in Efficacy/Tolerability Between Adolescent and Mixed-age Population

被引:26
作者
Balestrieri, Matteo [1 ]
Oriani, Maria Ginevra [2 ,3 ]
Simoncini, Annalisa [2 ,3 ]
Bellantuono, Cesario [2 ,3 ]
机构
[1] Univ Udine, Dept Psychiat, DISM, I-33100 Udine, Italy
[2] Univ Politecn Marche, United Hosp Ancona, Psychiat Unit, DMH, Ancona, Italy
[3] Univ Politecn Marche, Ancona, Italy
关键词
anorexia; psychotropic drugs; antidepressants; antipsychotics; adolescent; adult; review; DOUBLE-BLIND; OPEN-LABEL; OLANZAPINE TREATMENT; ADJUNCTIVE FLUOXETINE; INPATIENT TREATMENT; MEDICATION USE; OPEN TRIAL; EFFICACY; WEIGHT; QUETIAPINE;
D O I
10.1002/erv.2240
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background During the last 10years, the use of psychotropic medications in youth with psychiatric disorders, including eating disorders, has significantly increased, but their role in the treatment of adolescent anorexia nervosa is still controversial. Objective This paper aims to review the literature on the use of antidepressants and antipsychotics in adolescents with anorexia nervosa, comparing the efficacy and tolerability in this population with those reported in trials with patients not selected by age. Method A systematic review of the available literature published so far. Results Only few studies met the selection criteria. No strong evidence of beneficial effects was found in using antidepressants and antipsychotics neither in adults nor in adolescents. Side effects were more frequently reported in studies including adolescent population. Among psychotropic drugs, the majority of studies focused on olanzapine, which seems to have, in some studies, only positive effects on body mass index, eating disorder symptoms and functional impairment in both age groups. Copyright (c) 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
引用
收藏
页码:361 / 373
页数:13
相关论文
共 52 条
[1]   Report of the National Institutes of Health Workshop on Overcoming Barriers to Treatment Research in Anorexia Nervosa [J].
Agras, WS ;
Brandt, HA ;
Bulik, CM ;
Dolan-Sewell, R ;
Fairburn, CG ;
Halmi, KA ;
Herzog, DB ;
Jimerson, DC ;
Kaplan, AS ;
Kaye, WH ;
le Grange, D ;
Lock, J ;
Mitchell, JE ;
Rudorfer, MV ;
Street, LL ;
Striegel-Moore, R ;
Vitousek, KM ;
Walsh, BT ;
Wilfley, DE .
INTERNATIONAL JOURNAL OF EATING DISORDERS, 2004, 35 (04) :509-521
[2]   Does fluoxetine augment the inpatient treatment of anorexia nervosa? [J].
Attia, E ;
Haiman, C ;
Walsh, T ;
Flater, SR .
AMERICAN JOURNAL OF PSYCHIATRY, 1998, 155 (04) :548-551
[3]  
Attia E, 2008, P 14 EDRS M MONTR SE
[4]  
Attia E, 2011, PSYCHOL MED, V22, P1
[5]   An open trial of olanzapine in anorexia nervosa [J].
Barbarich, NC ;
McConaha, CW ;
Gaskill, J ;
La Via, M ;
Frank, GK ;
Achenbach, S ;
Plotnicov, KH ;
Kaye, WH .
JOURNAL OF CLINICAL PSYCHIATRY, 2004, 65 (11) :1480-1482
[6]   Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa [J].
Barbarich, NC ;
McConaha, CW ;
Halmi, KA ;
Gendall, K ;
Sunday, SR ;
Gaskill, J ;
La Via, M ;
Frank, GK ;
Brooks, S ;
Plotnicov, KH ;
Kaye, WH .
INTERNATIONAL JOURNAL OF EATING DISORDERS, 2004, 35 (01) :10-15
[7]   Olanzapine in the treatment of low body weight and obsessive thinking in women with anorexia nervosa: A randomized, double-blind, placebo-controlled trial [J].
Bissada, Hany ;
Tasca, Giorgio A. ;
Barber, Ann Marie ;
Bradwejn, Jacques .
AMERICAN JOURNAL OF PSYCHIATRY, 2008, 165 (10) :1281-1288
[8]   An open-label study of quetiapine in anorexia nervosa [J].
Bosanac, P. ;
Kurlender, S. ;
Norman, T. ;
Hallam, K. ;
Wesnes, K. ;
Manktelow, T. ;
Burrows, G. .
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2007, 22 (04) :223-230
[9]   Olanzapine therapy in anorexia nervosa: psychobiological effects [J].
Brambilla, Francesca ;
Garcia, Cristina Segura ;
Fassino, Secondo ;
Daga, Giovanni Abbate ;
Favaro, Angela ;
Santonastaso, Paolo ;
Ramaciotti, Carla ;
Bondi, Emilia ;
Mellado, Carmen ;
Borriello, Renata ;
Monteleone, Palmiero .
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2007, 22 (04) :197-204
[10]  
Carver A. E., 2002, P AC EAT DIS ANN M B