Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate are not transported by Concentrative Nucleoside Transporter 2

被引：6
作者：
Cusato, Jessica [1 ]
Calcagno, Andrea [1 ]
De Nicolo, Amedeo [1 ]
Mogyorosi, Karoly [2 ]
D'Avolio, Antonio [1 ]
Di Perri, Giovanni [1 ]
Bonora, Stefano [1 ]
机构：
[1] Univ Turin, Amedeo di Savoia Hosp, Dept Med Sci, Turin, Italy
[2] SOLVO Biotechnol, Kozep Fasor 52, H-6726 Szeged, Hungary
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2019年 / 94卷 / 02期
关键词：
TDF; TAF; SLC28A2; CNT2; Renal toxicity; HIV; HAART; POLYMORPHISMS;
D O I：
10.1016/j.diagmicrobio.2018.07.001
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Tenofovir-associated renal toxicity is influenced by several factors, including plasma exposure and genetic variants in transporter-encoding genes. Tenofovir plasma exposure has been associated with a polymorphism in SLC28A2 gene (encoding the concentrative nucleoside transporter 2, CNT2): particularly, SLC28A2 124 CT/FT genotype patients show higher plasma tenofovir concentrations, compared to CC group. In literature, substrate studies are lacking; for this reason, our aim was to understand if tenofovir and tenofovir- alafenamide are CNT2 substrates. We performed an in vitro study using CNT2 expressing MDCKII cells. We observed that tenofovir and tenofovir-alafenamide are not substrates of CNT2. Tenofovir-alafenamide influx pathway remains to be clarified. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：202 / 204
页数：3
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