Molecular mechanisms of metastasis

被引:65
作者
Hoon, Dave S. B. [1 ]
Kitago, Minoru
Kim, Joseph
Mori, Takuji
Piris, Adriano
Szyfelbein, Katherine
Mihm, Martin C., Jr.
Nathanson, S. David
Padera, Timothy P.
Chambers, Ann F.
Vantyghem, Sharon A.
MacDonald, Ian C.
Shivers, Steven C.
Alsarraj, Marwan
Reintgen, Douglas S.
Passlick, Bernward
Sienel, Wulf
Pantel, Klaus
机构
[1] John Wayne Canc Inst, Dept Mol Oncol, Santa Monica, CA 90404 USA
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02115 USA
[3] Josephine Ford Canc Ctr, Henry Ford Hlth Syst, Detroit, MI 48301 USA
[4] Massachusetts Gen Hosp, EL Steele Labs Tumor Biol, Boston, MA 02114 USA
[5] London Reg Canc Program, London, ON N6A 4L6, Canada
[6] Univ Western Ontario, Dept Med Biophys, London, ON N6A 5C1, Canada
[7] Lakeland Reg Canc Ctr, Lakeland, FL 33805 USA
[8] Univ Freiburg, Dept Thorac Surg, D-79106 Freiburg, Germany
[9] Univ Hamburg, Med Ctr, Inst Tumor Biol, D-20246 Hamburg, Germany
关键词
chemokines; intravital videoscopy; lymphatic vessels; lymph node; metastasis; oncogenes;
D O I
10.1007/s10555-006-8500-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A major topic covered at the First International Symposium on Cancer Metastasis and the Lymphovascular System was the molecular mechanisms of metastasis. This has become of major interest in recent years as we have discovered new metastasis-related genes and gained understanding of the molecular events of lymphatic metastasis. The symposium covered new aspects and important questions related to the events of metastasis in both humans and animals. The basic and clinical related research covered in this topic represented many disciplines. The presentations showed novel findings and at the same time, raised many new unanswered questions, indicating the limited knowledge we still have regarding the molecular events of metastasis. The hope is that further unraveling of the direct and indirect molecular events of lymphatic metastasis will lead to new approaches in developing effective therapeutics.
引用
收藏
页码:203 / 220
页数:18
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