Enhanced Photodynamic Efficiency of an Aptamer-Guided Fullerene Photosensitizer toward Tumor Cells

被引：35

作者：

Liu, Qiaoling ^{[1
]}

Xu, Li ^{[1
]}

Zhang, Xuejie ^{[1
]}

Li, Nan ^{[1
]}

Zheng, Junpeng ^{[1
]}

Guan, Mirong ^{[1
]}

Fang, Xiaohong ^{[1
]}

Wang, Chunru ^{[1
]}

Shu, Chunying ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2013年 / 8卷 / 10期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

aptamers; cancer; fullerenes; nanoparticles; photodynamic therapy; WATER-SOLUBLE FULLERENES; CANCER-CELLS; THERAPY; NANOPARTICLES; KERATINOCYTES; GENERATION; DELIVERY; CARRIER; GROWTH; C-60;

D O I：

10.1002/asia.201300039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fullerene-based photosensitizers exhibit great potential in photodynamic therapy (PDT). Based on the high photodynamic efficacy of trimalonic acid-modified C-70 fullerene (TF70), we constructed an aptamer-guided TF70 photosensitizer and investigated its photodynamic effect. Conjugation of the novel aptamer (named R13) could effectively enhance the PDT efficiency of TF70 against A549 lung cancer cells in the presence of serum. The lysosomal location of the TF70-R13 conjugate inside cells facilitates the production of intracellular reactive oxygen species (ROS), which can efficiently kill cells, under light irradiation. The enhanced photodynamic efficiency, along with its good biocompatibility in the dark, makes TF70-R13 a highly promising photosensitizer for tumor-specific PDT.

引用

页码：2370 / 2376

页数：7

共 37 条

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