Construction of a Spirooxindole Amide Library through Nitrile Hydrozirconation-Acylation-Cyclization Cascade

被引：16

作者：

LaPorte, Matthew G. ^{[1
]}

Tsegay, Sammi ^{[1
]}

Hong, Ki Bum ^{[1
]}

Lu, Chunliang ^{[1
]}

Fang, Cheng ^{[2
]}

Wang, Lirong ^{[2
]}

Xie, Xiang-Qun ^{[2
]}

Floreancig, Paul E. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Pharm, Computat Chem Genom Screening Ctr, Dept Chem Chem Methodol & Lib Dev, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Sch Pharm, Computat Chem Genom Screening Ctr, Dept Pharmaceut Sci, Pittsburgh, PA 15260 USA

来源：

ACS COMBINATORIAL SCIENCE | 2013年 / 15卷 / 07期

关键词：

nitrile hydrozirconation-acylation-cyclization; cascade; spirooxindole; CROSS-COUPLING REACTIONS; STEREOSELECTIVE-SYNTHESIS; CHEMICAL DIVERSITY; OXINDOLES;

D O I：

10.1021/co4000387

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections.

引用

页码：344 / 349

页数：6

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