Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation

被引：66

作者：

Durholz, Kerstin ^{[1
,2
,3
]}

Hofmann, Jorg ^{[4
]}

Iljazovic, Aida ^{[5
]}

Hager, Julian ^{[1
,2
,3
]}

Lucas, Sebastien ^{[1
,2
,3
]}

Sarter, Kerstin ^{[1
,2
,3
]}

Strowig, Till ^{[5
]}

Bang, Holger ^{[6
]}

Rech, Jurgen ^{[1
,2
,3
]}

Schett, Georg ^{[1
,2
,3
]}

Zaiss, Mario M. ^{[1
,2
,3
]}

机构：

[1] Friedrich Alexander Univ FAU Erlangen Nurnberg, Dept Internal Med Rheumatol & Immunol 3, D-91054 Erlangen, Germany

[2] Univ Klinikum Erlangen, D-91054 Erlangen, Germany

[3] Deutsch Zentrum Immuntherapie DZI, D-91054 Erlangen, Germany

[4] Friedrich Alexander Univ FAU, Div Biochem, Dept Biol, D-91058 Erlangen, Germany

[5] Helmholtz Ctr Infect Res, D-38124 Braunschweig, Germany

[6] Melio Care GmbH, D-91080 Marloffstein, Germany

来源：

NUTRIENTS | 2020年 / 12卷 / 10期

关键词：

high-fiber diet (HFD); microbial metabolites; short chain fatty acids (SCFA); CHAIN FATTY-ACIDS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; RHEUMATOID-ARTHRITIS; THERAPEUTIC TARGET; EPITHELIAL-CELLS; MCP-1; INTERLEUKIN-18; METABOLITES; IL-33; DIFFERENTIATION;

D O I：

10.3390/nu12103207

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Chronic inflammatory diseases are often initiated and guided by the release of proinflammatory mediators. Rheumatoid arthritis (RA) is caused by an imbalance between the pro- and anti-inflammatory mediators in the joints, thereby favoring chronic inflammation and joint damage. Here, we investigate if short-term high-fiber dietary intervention shifts this towards anti-inflammatory mediators. Healthy controls (n = 10) and RA patients (n = 29) under routine care received daily high-fiber bars for 15 or 30 days, respectively. Stool and sera were analyzed for pro- and anti-inflammatory mediators. A high-fiber dietary intervention resulted in increased anti-inflammatory short-chain fatty acids (SCFA), decreased proarthritic cytokine concentrations, along with a durable shift in the Firmicutes-to-Bacteroidetes ratio. Together, these results further strengthen high-fiber dietary interventions as a practical approach complementing existing pharmacological therapies.

引用

页码：1 / 11

页数：11

共 55 条

[1] Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[2] Short Chain Fatty Acids (SCFA) Reprogram Gene Expression in Human Malignant Epithelial and Lymphoid Cells [J].

Astakhova, Lidiia ;

Ngara, Mtakai ;

Babich, Olga ;

Prosekov, Aleksandr ;

Asyakina, Lyudmila ;

Dyshlyuk, Lyubov ;

Midtvedt, Tore ;

Zhou, Xiaoying ;

Ernberg, Ingemar ;

Matskova, Liudmila .

PLOS ONE, 2016, 11 (07)

[3] Gut microbiota-derived propionate reduces cancer cell proliferation in the liver [J].

Bindels, L. B. ;

Porporato, P. ;

Dewulf, E. M. ;

Verrax, J. ;

Neyrinck, A. M. ;

Martin, J. C. ;

Scott, K. P. ;

Calderon, P. Buc ;

Feron, O. ;

Muccioli, G. G. ;

Sonveaux, P. ;

Cani, P. D. ;

Delzenne, N. M. .

BRITISH JOURNAL OF CANCER, 2012, 107 (08) :1337-1344

[4] Molecular analysis of the effect of short-chain fatty acids on intestinal cell proliferation [J].

Blottière, HM ;

Buecher, B ;

Galmiche, JP ;

Cherbut, C .

PROCEEDINGS OF THE NUTRITION SOCIETY, 2003, 62 (01) :101-106

[5] Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample [J].

Caporaso, J. Gregory ;

Lauber, Christian L. ;

Walters, William A. ;

Berg-Lyons, Donna ;

Lozupone, Catherine A. ;

Turnbaugh, Peter J. ;

Fierer, Noah ;

Knight, Rob .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 :4516-4522

[6] Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E2 and cytokines [J].

Cox, Mary Ann ;

Jackson, James ;

Stanton, Michaela ;

Rojas-Triana, Alberto ;

Bober, Loretta ;

Laverty, Maureen ;

Yang, Xiaoxin ;

Zhu, Feng ;

Liu, Jianjun ;

Wang, Suke ;

Monsma, Frederick ;

Vassileva, Galya ;

Maguire, Maureen ;

Gustafson, Eric ;

Bayne, Marvin ;

Chou, Chuan-Chu ;

Lundell, Daniel ;

Jenh, Chung-Her .

WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (44) :5549-5557

[7] Cellular targets of interleukin-18 in rheumatoid arthritis [J].

Dai, Sheng-Ming ;

Shan, Zheng-Zheng ;

Xu, Huji ;

Nishioka, Kusuki .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (11) :1411-1418

[8] Interleukin-18, rheumatoid arthritis, and tissue destruction [J].

Dayer, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (10) :1337-1339

[9] High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome [J].

De Filippis, Francesca ;

Pellegrini, Nicoletta ;

Vannini, Lucia ;

Jeffery, Ian B. ;

La Storia, Antonietta ;

Laghi, Luca ;

Serrazanetti, Diana I. ;

Di Cagno, Raffaella ;

Ferrocino, Ilario ;

Lazzi, Camilla ;

Turroni, Silvia ;

Cocolin, Luca ;

Brigidi, Patrizia ;

Neviani, Erasmo ;

Gobbetti, Marco ;

O'Toole, Paul W. ;

Ercolini, Danilo .

GUT, 2016, 65 (11) :1812-1821

[10] Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa [J].

De Filippo, Carlotta ;

Cavalieri, Duccio ;

Di Paola, Monica ;

Ramazzotti, Matteo ;

Poullet, Jean Baptiste ;

Massart, Sebastien ;

Collini, Silvia ;

Pieraccini, Giuseppe ;

Lionetti, Paolo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) :14691-14696

← 1 2 3 4 5 6 →