Response of the rat spinal cord to X-ray microbeams

被引：57

作者：

Laissue, Jean A. ^{[1
]}

Bartzsch, Stefan ^{[2
]}

Blattmann, Hans ^{[1
]}

Braeuer-Krisch, Elke ^{[3
]}

Bravin, Alberto ^{[3
]}

Dallery, Dominique ^{[3
]}

Djonov, Valentin ^{[4
]}

Hanson, Albert L. ^{[5
]}

Hopewell, John W. ^{[6
]}

Kaser-Hotz, Barbara ^{[7
]}

Keyrilainen, Jani ^{[8
]}

Laissue, Pierre Philippe ^{[9
]}

Miura, Michiko ^{[5
]}

Serduc, Raphael ^{[10
,11
]}

Siegbahn, Albert E. ^{[12
]}

Slatkin, Daniel N. ^{[13
]}

机构：

[1] Univ Bern, Inst Pathol, CH-3012 Bern, Switzerland

[2] Deutsch Krebsforschungszentrum, Heidelberg, Germany

[3] European Synchrotron Radiat Facil, F-38043 Grenoble, France

[4] Univ Bern, Inst Anat, Bern, Switzerland

[5] Brookhaven Natl Lab, Upton, NY 11973 USA

[6] Univ Oxford, Particle Therapy Canc Res Inst, Oxford OX1 2JD, England

[7] Anim Oncol & Imaging Ctr, Hunenberg, Switzerland

[8] Univ Helsinki, Cent Hosp, Dept Phys, FIN-00014 Helsinki, Finland

[9] Univ Essex, Dept Biol Sci, Colchester CO4 3SQ, Essex, England

[10] INSERM, U836, Grenoble, France

[11] Univ Grenoble 1, Grenoble Inst Neurosci, Grenoble, France

[12] Karolinska Univ Hosp, Dept Med Phys, Stockholm, Sweden

[13] Nanoprobes Inc, Yaphank, NY USA

来源：

RADIOTHERAPY AND ONCOLOGY | 2013年 / 106卷 / 01期

关键词：

Spinal cord response; Synchrotron X-rays; Microbeams; CENTRAL-NERVOUS-SYSTEM; RADIATION-THERAPY; IRRADIATION; BRAIN; TOLERANCE; REPAIR; BEAMS;

D O I：

10.1016/j.radonc.2012.12.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: To quantify the late,close-related responses of the rat cervical spinal cord to Xray irradiations by an array of microbeams or by a single millimeter beam. Materials and methods: Necks of anesthetized rats were irradiated transversely by an 11 mm wide array of 52 parallel, 35 gm wide, vertical X-ray microbeams, separated by 210 mu m intervals between centers. Comparison was made with rats irradiated with a 1.35 mm wide single beam of similar X-rays. Rats were killed when paresis developed, or up to 383 days post irradiation (dpi). Results: Microbeam peak/valley doses of approximate to 1357/12.7 Gy to 715/25.4 Gy to an 11 mm long segment of the spinal cord, or single beam doses of approximate to 146-454 Gy to a 1.35 mm long segment caused foreleg paresis and histopathologically verified spinal cord damage; rats exposed to peak/valley doses up to 253/9 Gy were paresis-free at 383 dpi. Conclusions: Whereas microbeam radiation therapy [MRT] for malignant gliomas implanted in rat brains can be safe, palliative or curative, the high tolerance of normal rat spinal cords to similar microbeam exposures justifies testing MRT for autochthonous malignancies in the central nervous system of larger animals with a view to subsequent clinical applications. (C) 2012 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 106 (2013) 106-111

引用

页码：106 / 111

页数：6

共 32 条

[1] Variation in radiation sensitivity and repair kinetics in different parts of the spinal cord [J].