Bystander-Activated Memory CD8 T Cells Control Early Pathogen Load in an Innate-like, NKG2D-Dependent Manner

被引：137

作者：

Chu, Talyn ^{[1
]}

Tyznik, Aaron J. ^{[2
]}

Roepke, Sarah ^{[1
]}

Berkley, Amy M. ^{[3
]}

Woodward-Davis, Amanda ^{[3
]}

Pattacini, Laura ^{[1
]}

Bevan, Michael J. ^{[3
]}

Zehn, Dietmar ^{[4
,5
]}

Prlic, Martin ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

[2] La Jolla Inst Allergy & Immunol, Div Dev Immunol, La Jolla, CA 92037 USA

[3] Univ Washington, Howard Hughes Med Inst, Dept Immunol, Seattle, WA 98195 USA

[4] SVRI, CH-1066 Epalinges, Switzerland

[5] Univ Lausanne Hosp, Dept Med, Div Immunol & Allergy, CH-1011 Lausanne, Switzerland

来源：

CELL REPORTS | 2013年 / 3卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

LISTERIA-MONOCYTOGENES; RECEPTOR; EXPRESSION; PATHWAY; VIRUS; DIFFERENTIATION; INDUCTION; PHENOTYPE; ANTIGEN; CTL;

D O I：

10.1016/j.celrep.2013.02.020

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During an infection the antigen-nonspecific memory CD8 T cell compartment is not simply an inert pool of cells, but becomes activated and cytotoxic. It is unknown how these cells contribute to the clearance of an infection. We measured the strength of T cell receptor (TCR) signals that bystander-activated, cytotoxic CD8 T cells (BA-CTLs) receive in vivo and found evidence of limited TCR signaling. Given this marginal contribution of the TCR, we asked how BA-CTLs identify infected target cells. We show that target cells express NKG2D ligands following bacterial infection and demonstrate that BA-CTLs directly eliminate these target cells in an innate-like, NKG2D-dependent manner. Selective inhibition of BA-CTL-mediated killing led to a significant defect in pathogen clearance. Together, these data suggest an innate role for memory CD8 T cells in the early immune response before the onset of a de novo generated, antigen-specific CD8 T cell response.

引用

页码：701 / 708

页数：8