Microwave-induced biomimetic approach for hydroxyapatite coatings of chitosan scaffolds

被引：53

作者：

Bayrak, Gokce Kaynak ^{[1
]}

Demirtas, T. Tolga ^{[1
]}

Gumusderelioglu, Menemse ^{[1
,2
]}

机构：

[1] Hacettepe Univ, Dept Bioengn, Ankara, Turkey

[2] Hacettepe Univ, Dept Chem Engn, Ankara, Turkey

来源：

CARBOHYDRATE POLYMERS | 2017年 / 157卷

关键词：

Simulated body fluid; Microwave; Bone-tissue engineering; Hydroxyapatite; Chitosan; MESENCHYMAL STEM-CELLS; OSTEOBLAST DIFFERENTIATION; APATITE FORMATION; BONELIKE APATITE; MAGNESIUM ALLOY; IN-VITRO; MICROPARTICLES; MINERALIZATION; COMPOSITES; GROWTH;

D O I：

10.1016/j.carbpol.2016.10.016

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Simulated body fluid (SBF) can form calcium phosphates on osteoinductive materials, so it is widely used for coating of bone scaffolds to mimic natural extracellular matrix (ECM). However, difficulties of bulk coating in 3D scaffolds and the necessity of long process times are the common problems for coating with SBF. In the present study, a microwave-assisted process was developed for rapid and internal coating of chitosan scaffolds. The scaffolds were fabricated as superporous hydrogel (SPH) by combining microwave irradiation and gas foaming methods. Then, they were immersed into 10x SBF-like solution and homogenous bone-like hydroxyapatite (HA) coating was achieved by microwave treatment at 600 W without the need of any nucleating agent. Cell culture studies with MC3T3-E1 preosteoblasts showed that microwave-assisted biomimetic HA coating process could be evaluated as an efficient and rapid method to obtain composite scaffolds for bone tissue engineering. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：803 / 813

页数：11

共 45 条

[31] Nucleation and growth of biomimetic apatite layers on 3D plotted biodegradable polymeric scaffolds: Effect of static and dynamic coating conditions [J].