Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from Stellera chamaejasme

被引：53

作者：

Asada, Yoshihisa ^{[1
]}

Sukemori, Aya ^{[2
]}

Watanabe, Takashi ^{[3
]}

Malla, Kuber J. ^{[4
]}

Yoshikawa, Takafumi ^{[2
]}

Li, Wei ^{[5
]}

Kuang, Xinzhu ^{[5
]}

Koike, Kazuo ^{[5
]}

Chen, Chin-Ho ^{[6
]}

Akiyama, Toshiyuki ^{[7
]}

Qian, Keduo ^{[7
]}

Nakagawa-Goto, Kyoko ^{[7
]}

Morris-Natschke, Susan L. ^{[7
]}

Lu, Yan ^{[7
]}

Lee, Kuo-Hsiung ^{[7
,8
]}

机构：

[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Noda, Chiba 2788510, Japan

[2] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088641, Japan

[3] Kochi Univ Technol, Lab Studying Complementary & Med Resources, Kochi 7828502, Japan

[4] Dept Plant Resources, Kathmandu, Nepal

[5] Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan

[6] Duke Univ, Med Ctr, SORF, Durham, NC 27710 USA

[7] Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA

[8] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 05期

关键词：

ESTERS;

D O I：

10.1021/np300815t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3-5 showed potent anti-HIV activity (EC90 0.00056-0.0068 mu M) and relatively low or no cytotoxicity (IC50 4.4-17.2 mu M). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates.

引用

页码：852 / 857

页数：6