Intestinal 5-hydroxytryptamine and mast cell infiltration in rat experimental colitis

被引：20

作者：

Magro, F

Fraga, S

Azevedo, I

Soares-Da-Silva, P ^{[1
]}

机构：

[1] Univ Porto, Fac Med, Inst Pharmacol & Therapeut, P-4200319 Oporto, Portugal

[2] Univ Porto, Fac Med, Dept Biochem, P-4200319 Oporto, Portugal

来源：

DIGESTIVE DISEASES AND SCIENCES | 2006年 / 51卷 / 03期

关键词：

colitis; 5-hydroxytryptamine; mast cells;

D O I：

10.1007/s10620-006-3161-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The present study evaluated the extent of dysfunction of the 5-hydroxytryptaminergic system in inflamed (distal colon) and noninflamed segments (Jejunum and ileum) after intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in the rat. Dexamethasone was administered to control rats and TNBS-treated animals before and for 7 days after TNBS treatment. Tissue levels of 5-hydroxytryptamine (5-HT) in the inflamed colon were higher than in controls. The density of mast cells was also markedly increased. Treatment with dexamethasone attenuated the inflammatory response but did not prevent the increase in colonic 5-HT. In the noninflamed jejunum and terminal ileum. 5-HT tissue levels were markedly increased, but treatment with dexamethasone prevented this increase. It is concluded that the increase in 5-HT levels in the inflamed colon in TNBS-induced colitis may result from mast cell infiltration. In the noninflamed intestine, 5-HT tissue levels were also increased, favoring the view of a generalized mast cell infiltration.

引用

页码：495 / 501

页数：7

共 20 条

[1]

CAMILLERI M, 2002, GUT, V51, P81

[2] Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters [J].