Preparation and characterization of nano-sized hydroxyapatite/alginate/chitosan composite scaffolds for bone tissue engineering

被引：187

作者：

Kim, Hye-Lee ^{[1
]}

Jung, Gil-Yong ^{[2
]}

Yoon, Jun-Ho ^{[1
]}

Han, Jung-Suk ^{[2
,3
,4
]}

Park, Yoon-Jeong ^{[2
,5
,6
]}

Kim, Do-Gyoon ^{[7
]}

Zhang, Miqin ^{[8
]}

Kim, Dae-Joon ^{[1
]}

机构：

[1] Sejong Univ, Dept Adv Mat Engn, Seoul 143747, South Korea

[2] Seoul Natl Univ, Interdisciplinary Program Bioengn, Seoul 152742, South Korea

[3] Seoul Natl Univ, Sch Dent, Dept Prosthodont, Seoul 110749, South Korea

[4] Seoul Natl Univ, Sch Dent, Dent Res Ctr, Seoul 110749, South Korea

[5] Seoul Natl Univ, Sch Dent, Dept Craniomaxillofacial Reconstruct Sci, Seoul 110749, South Korea

[6] Seoul Natl Univ, Sch Dent, Dent Res Inst, Seoul 110749, South Korea

[7] Ohio State Univ, Coll Dent, Div Orthodont, Columbus, OH 43210 USA

[8] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2015年 / 54卷

基金：

新加坡国家研究基金会;

关键词：

Hydroxyapatite; Chitosan; Alginate; Porous scaffold; Bone tissue engineering; CHITOSAN; ALGINATE;

D O I：

10.1016/j.msec.2015.04.033

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The aim of this study was to develop chitosan composite scaffolds with high strength and controlled pore structures by homogenously dispersed nano-sized hydroxyapatite (nano-HAp) powders. In the fabrication of composite scaffolds, nano-HAp powders distributed in an alginate (AG) solution with a pH higher than 10 were mixed with a chitosan (CS) solution and then freeze dried. While the HAp content increased up to 70 wt.%, the compressive strength and the elastic modulus of the composite scaffolds significantly increased from 0.27 MPa and 4.42 MPa to 0.68 MPa and 13.35 MPa, respectively. Higher content of the HAp also helped develop more differentiation and mineralization of the MC3T3-E1 cells on the composite scaffolds. The uniform pore structure and the excellent mechanical properties of the HAp/CS composite scaffolds likely resulted from the use of the AG solution at pH 10 as a dispersant for the nano-HAp powders. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：20 / 25

页数：6

共 30 条

[1] Design and characterization of a novel chitosan/nanocrystalline calcium phosphate composite scaffold for bone regeneration [J].