The convenient synthesis and reaction of 2-(arylthio)phenols under ligand-free conditions: arylthioquinone preparation through cascade C-H functionalization and oxidation from arylthiols and aryl iodides

被引：7

作者：

Wang, Dawei ^{[1
]}

Yu, Xiaoli ^{[1
]}

Wang, Likui ^{[1
]}

Yao, Wei ^{[1
]}

Xu, Zhaojun ^{[1
]}

Wan, Huida ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Chem & Mat Engn, Key Lab Food Colloids & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 47期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

C-H functionalization; Alylthiols; Quinone; 2-(Arylthio)phenols; Copper; FATTY-ACID BIOSYNTHESIS; CARBON-HYDROGEN BONDS; PROTEIN SYNTHASE-III; ACTIVATION; ARYLATION; SUBSTITUTION; DERIVATIVES; ANTIFUNGAL; ANTICANCER; INHIBITORS;

D O I：

10.1016/j.tetlet.2016.10.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and simple method for copper-catalyzed synthesis of 2-(arylthio)phenols through C-H functionalization of arylthiols and aryl iodides was developed under ligand-free conditions without nitrogen protection. In addition, arylthioquinone derivatives were very easily prepared for one more step of oxidation with moderate to good yields. This provide an alternative and efficient way to 2-(arylthio)phenols and arylthioquinone derivatives smoothly without using ligands and nitrogen protection or expensive arylboronic acids. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：5211 / 5214

页数：4

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