Quantitative and qualitative analysis of proteins in fresh frozen plasma obtained from whole blood donations and prepared with two photochemical treatments

被引：16

作者：

Cid, Joan ^{[1
]}

Ramiro, Laia ^{[1
]}

Martinez, Nuria ^{[1
]}

Palomo, Marta ^{[2
]}

Magallon, Olga ^{[1
]}

Claparos, Montse ^{[1
]}

Ortiz, Pilar ^{[1
]}

Puig, Lluis ^{[1
]}

Pla, Ramon Pau ^{[1
]}

机构：

[1] Banc Sang & Teixits, Barcelona, Spain

[2] Univ Barcelona, IDIBAPS, Hosp Clin, Serv Hemoterapia Hemostasia,CDB, E-08007 Barcelona, Spain

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2008年 / 39卷 / 02期

关键词：

D O I：

10.1016/j.transci.2008.07.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thirty-six fresh frozen plasma (FFP) units obtained from whole blood donations were used for 12 replicate experiments. For each replicate experiment, three ABO-matched FFP units were pooled and divided into three units containing different volumes of identical plasma. One unit was used as control FFP, one unit was treated with methylene blue plus visible light and one unit was treated with amotosalen and UVA light. The overall coagulation factor levels were better maintained in untreated FFP than in photochemically treated plasma. However, treated-plasma by both photochemical methods maintained coagulation factor levels that met or exceeded the European Pharmacopeia requirements for therapeutic plasma. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：115 / 121

页数：7

共 29 条

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