Efficient copper-catalyzed intramolecular N-arylation for the synthesis of oxindoles

被引：24
|
作者：
Jhan, Yu-Huei [1 ]
Kang, Ting-Wei [1 ]
Hsieh, Jen-Chieh [1 ]
机构：
[1] Tamkang Univ, Dept Chem, New Taipei City 25137, Taiwan
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 09期
关键词：
Cu2O; Ullmann coupling; Benzene-1,2-diamine; Oxindole; N-arylation; ASYMMETRIC HECK REACTIONS; ENANTIOSELECTIVE SYNTHESIS; ALPHA-ARYLATION; C-H; AMIDATION; BEARING; AMIDES;
D O I：
10.1016/j.tetlet.2012.12.082
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient copper-catalyzed intramolecular N-arylation was performed by using substituted 2-(2-bromoaryl)acetamide with small amount of Cu2O and benzene-1,2-diamine as catalytic system under aerobic conditions, which provided good to excellent yields of oxindoles with tolerance of a wide variety of substrates. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1155 / 1159
页数：5
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