Thrombotic Microangiopathy and the Kidney

被引：252

作者：

Brocklebank, Vicky ^{[1
,2
]}

Wood, Katrina M. ^{[3
]}

Kavanagh, David ^{[1
,2
]}

机构：

[1] Newcastle Upon Tyne Hosp Natl Hlth Serv Fdn Trust, Natl Renal Complement Therapeut Ctr, Newcastle Upon Tyne, Tyne & Wear, England

[2] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England

[3] Newcastle Upon Tyne Hosp Natl Hlth Serv Fdn Trust, Dept Cellular Pathol, Newcastle Upon Tyne, Tyne & Wear, England

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2018年 / 13卷 / 02期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

HEMOLYTIC-UREMIC SYNDROME; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; COMPLEMENT INHIBITOR ECULIZUMAB; FACTOR-H-AUTOANTIBODIES; THROMBOCYTOPENIC PURPURA; ESCHERICHIA-COLI; RENAL-FAILURE; MALIGNANT HYPERTENSION; ALTERNATIVE PATHWAY; PLASMA-EXCHANGE;

D O I：

10.2215/CJN.00620117

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombotic microangiopathy can manifest in a diverse range of diseases and is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury, including AKI. It can be associated with significant morbidity and mortality, but a systematic approach to investigation and prompt initiation of supportive management and, in some cases, effective specific treatment can result in good outcomes. This review considers the classification, pathology, epidemiology, characteristics, and pathogenesis of the thrombotic microangiopathies, and outlines a pragmatic approach to diagnosis and management.

引用

页码：300 / 317

页数：18

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