Thrombotic Microangiopathy and the Kidney

被引：252
作者：
Brocklebank, Vicky [1 ,2 ]
Wood, Katrina M. [3 ]
Kavanagh, David [1 ,2 ]
机构：
[1] Newcastle Upon Tyne Hosp Natl Hlth Serv Fdn Trust, Natl Renal Complement Therapeut Ctr, Newcastle Upon Tyne, Tyne & Wear, England
[2] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
[3] Newcastle Upon Tyne Hosp Natl Hlth Serv Fdn Trust, Dept Cellular Pathol, Newcastle Upon Tyne, Tyne & Wear, England
来源：
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2018年 / 13卷 / 02期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
HEMOLYTIC-UREMIC SYNDROME; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; COMPLEMENT INHIBITOR ECULIZUMAB; FACTOR-H-AUTOANTIBODIES; THROMBOCYTOPENIC PURPURA; ESCHERICHIA-COLI; RENAL-FAILURE; MALIGNANT HYPERTENSION; ALTERNATIVE PATHWAY; PLASMA-EXCHANGE;
D O I：
10.2215/CJN.00620117
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Thrombotic microangiopathy can manifest in a diverse range of diseases and is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury, including AKI. It can be associated with significant morbidity and mortality, but a systematic approach to investigation and prompt initiation of supportive management and, in some cases, effective specific treatment can result in good outcomes. This review considers the classification, pathology, epidemiology, characteristics, and pathogenesis of the thrombotic microangiopathies, and outlines a pragmatic approach to diagnosis and management.
引用
收藏
页码：300 / 317
页数：18
相关论文
共 129 条
[1]   Clinical Features of Malignant Hypertension with Thrombotic Microangiopathy [J].
Akimoto, Tetsu ;
Muto, Shigeaki ;
Ito, Chiharu ;
Takahashi, Hideaki ;
Takeda, Shinichi ;
Ando, Yasuhiro ;
Kusano, Eiji .
CLINICAL AND EXPERIMENTAL HYPERTENSION, 2011, 33 (02) :77-83
[2]   Drug-induced thrombotic microangiopathy: a systematic review of published reports [J].
Al-Nouri, Zayd L. ;
Reese, Jessica A. ;
Terrell, Deirdra R. ;
Vesely, Sara K. ;
George, James N. .
BLOOD, 2015, 125 (04) :616-618
[3]   Serologic response to meningococcal vaccination in patients with paroxysmal nocturnal hemoglobinuria (PNH) chronically treated with the terminal complement inhibitor eculizumab [J].
Alashkar, Ferras ;
Vance, Colin ;
Herich-Terhuerne, Doerte ;
Preising, Nicole ;
Duehrsen, Ulrich ;
Roeth, Alexander .
ANNALS OF HEMATOLOGY, 2017, 96 (04) :589-596
[4]   Light at the end of the TUNEL: HIV-associated thrombotic microangiopathy [J].
Alpers, CE ;
Madias, NE ;
Harrington, T ;
Levey, AS ;
Balakrishnan, V .
KIDNEY INTERNATIONAL, 2003, 63 (01) :385-396
[5]   Long-term renal outcome in patients with malignant hypertension: a retrospective cohort study [J].
Amraoui, Fouad ;
Bos, Sarah ;
Vogt, Liffert ;
van den Born, Bert-Jan .
BMC NEPHROLOGY, 2012, 13
[6]   Streptococcus pneumoniae-associated Hemolytic Uremic Syndrome Among Children in North America [J].
Banerjee, Ritu ;
Hersh, Adam L. ;
Newland, Jason ;
Beekmann, Susan E. ;
Polgreen, Philip M. ;
Bender, Jeffrey ;
Shaw, Jana ;
Copelovitch, Lawrence ;
Kaplan, Bernard S. ;
Shah, Samir S. .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2011, 30 (09) :736-739
[7]   Evaluation of Clinical Outcomes and Renal Vascular Pathology among Patients with Lupus [J].
Barber, Claire ;
Herzenberg, Andrew ;
Aghdassi, Ellie ;
Su, Jiandong ;
Lou, Wendy ;
Qian, Gan ;
Yip, Jonathan ;
Nasr, Samih H. ;
Thomas, David ;
Scholey, James W. ;
Wither, Joan ;
Urowitz, Murray ;
Gladman, Dafna ;
Reich, Heather ;
Fortin, Paul R. .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 7 (05) :757-764
[8]   Renal Thrombotic Microangiopathy in Proliferative Lupus Nephritis: Risk Factors and Clinical Outcomes: A Case-Control Study [J].
Barrera-Vargas, Ana ;
Rosado-Canto, Rodrigo ;
Merayo-Chalico, Javier ;
Arreola-Guerra, Jose M. ;
Mejia-Vilet, Juan M. ;
Correa-Rotter, Ricardo ;
Gomez-Martin, Diana ;
Alcocer-Varela, Jorge .
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2016, 22 (05) :235-240
[9]   Renal thrombotic microangiopathy in patients with cblC defect: review of an under-recognized entity [J].
Beck, Bodo B. ;
van Spronsen, FrancJan ;
Diepstra, Arjan ;
Berger, Rolf M. F. ;
Komhoff, Martin .
PEDIATRIC NEPHROLOGY, 2017, 32 (05) :733-741
[10]   HIV-associated thrombotic microangiopathy in the era of highly active antiretroviral therapy: An observational study [J].
Becker, S ;
Fusco, G ;
Fusco, J ;
Balu, R ;
Gangjee, S ;
Brennan, C ;
Feinberg, J .
CLINICAL INFECTIOUS DISEASES, 2004, 39 :S267-S275
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