Iridium/copper-cocatalyzed asymmetric ring opening reaction of azabenzonorbornadienes with amines

被引：32

作者：

Zeng, Chaoyuan ^{[1
]}

Yang, Fan ^{[1
]}

Chen, Jingchao ^{[1
]}

Wang, Jun ^{[2
]}

Fan, Baomin ^{[1
]}

机构：

[1] Yunnan Minzu Univ, YMU HKBU Joint Lab Tradit Nat Med, Kunming 650500, Peoples R China

[2] South Univ Sci & Technol China, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 31期

基金：

中国国家自然科学基金;

关键词：

AZABICYCLIC ALKENES; OXABENZONORBORNADIENES; 1,2-DIAMINES; DERIVATIVES; DIAMINES; LIGANDS;

D O I：

10.1039/c5ob01243k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A combination of iridium/copper associated with (R)-Difluorphos catalyst for the asymmetric ring opening reaction of azabenzonorbornadienes with amines was developed, which afforded chiral trans-vicinal diamines in 80-97% yields with 93-95% enantioselectivities.

引用

页码：8425 / 8428

页数：4

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