Synthesis and Antimicrobial Activities of a Series of 2,5-Substituent 1,4-Cyclohexanedione Derivatives

被引：0

作者：

Liu, Hui-Lian ^{[1
]}

Wang, Qing-Zhong ^{[1
]}

Guo, Shu-Hua ^{[1
]}

机构：

[1] Weifang Univ, Coll Bioengn, Microscale Sci Inst, Weifang 261061, Shandong, Peoples R China

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 03期

关键词：

Cyclohexanedione derivatives; Antimicrobial activities; Structure-activity relationships;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 2,5-substituent 1,4-cyclohexanedione derivatives compounds were designed and synthesized. Their structures were identified 1 by elemental analysis, H-1 NMR, IR spectra, Their assayed antibacterial (Escherichia coli, Bacillus subtilis) and antifungal (Candida albicans) activities were also evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The results of I. biological test showed 2,5-dibenzylformate 1,4-cyclohexanedione (11) and 2,5-diformanilide 1,4-cyclohexanedione (12) have favorable I antimicrobial activity with MICs of 26.7, 33.6, 24.2 and 32.3 mu g/mL against Escherichia coli and Bacillus subtilis, respectively.

引用

页码：1349 / 1352

页数：4

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