NO inhibitory guaianolide-derived terpenoids from Artemisia argyi

被引：65
作者：
Wang, Shu [1 ]
Li, Jun [2 ]
Sun, Jian [1 ]
Zeng, Ke-wu [1 ]
Cui, Jing-rong [1 ]
Jiang, Yong [1 ]
Tu, Peng-fei [1 ]
机构：
[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[2] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
来源：
FITOTERAPIA | 2013年 / 85卷
基金：
中国国家自然科学基金;
关键词：
Artemisia argyi; Guaianolide-derived terpenoid; Absolute configuration; Nitric oxide; FARNESYL-PROTEIN TRANSFERASE; SESQUITERPENE LACTONES; NITRIC-OXIDE; DIMERIC GUAIANOLIDES; CIRCULAR-DICHROISM; ANTITUMOR-ACTIVITY; CONSTITUENTS; CHEMOSENSITIVITY; ARTEMINOLIDE; INFLAMMATION;
D O I：
10.1016/j.fitote.2012.12.005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An unusual dimeric guaianolide, artemilinin A (1) and a sesquiterpene-monoterpene lactone, isoartemisolide (2), were isolated from the leaves of Artemisia argyi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ES1MS, 1D- and 2D-NMR), and the absolute configurations were determined by CD spectra and quantum chemical ECD calculation. Furthermore, in in vitro assay, compound 2 exhibited pronounced inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 4.00 mu M. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：169 / 175
页数：7
相关论文
共 45 条
[1]  
[Anonymous], 2010, SYB SOFTW VERS X 1 1
[2]  
[Anonymous], 2011, SPECDIS VERSION 1 53
[3]   Role of nitric oxide in inflammatory conditions [J].
Blantz, RC ;
Munger, K .
NEPHRON, 2002, 90 (04) :373-378
[4]  
CARMICHAEL J, 1987, CANCER RES, V47, P936
[5]  
Clancy RM, 1998, ARTHRITIS RHEUM-US, V41, P1141, DOI 10.1002/1529-0131(199807)41:7<1141::AID-ART2>3.0.CO
[6]  
2-S
[7]  
Frisch M, 2015, Gaussian 09, revision a 02
[8]   ANALYSIS OF NITRATE, NITRITE, AND [N-15]-LABELED NITRATE IN BIOLOGICAL-FLUIDS [J].
GREEN, LC ;
WAGNER, DA ;
GLOGOWSKI, J ;
SKIPPER, PL ;
WISHNOK, JS ;
TANNENBAUM, SR .
ANALYTICAL BIOCHEMISTRY, 1982, 126 (01) :131-138
[9]   Inhibitors of the LPS-induced NF-κB activation from Artemisia sylvatica [J].
Hui, ZJ ;
Lee, JH ;
Lee, D ;
Hong, YS ;
Kim, YH ;
Lee, JJ .
PHYTOCHEMISTRY, 2004, 65 (15) :2247-2253
[10]  
Jiangsu New Medical College, 1986, DICT TRAD CHIN MED, P559
12345