Fully Implanted Brain-Computer Interface in a Locked-In Patient with ALS

被引：355

作者：

Vansteensel, Mariska J. ^{[1
]}

Pels, Elmar G. M. ^{[1
]}

Bleichner, Martin G. ^{[3
]}

Branco, Mariana P. ^{[1
]}

Denison, Timothy ^{[4
]}

Freudenburg, Zachary V. ^{[1
]}

Gosselaar, Peter ^{[1
]}

Leinders, Sacha ^{[1
]}

Ottens, Thomas H. ^{[2
]}

Van den Boom, Max A. ^{[1
]}

Van Rijen, Peter C. ^{[1
]}

Aarnoutse, Erik J. ^{[1
]}

Ramsey, Nick F. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol & Neurosurg, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Anesthesiol, Utrecht, Netherlands

[3] Carl von Ossietzky Univ Oldenburg, Cluster Excellence Hearing4all, European Med Sch, Neuropsychol Lab,Dept Psychol, Oldenburg, Germany

[4] Medtronic, Neuromodulat Core Technol, Minneapolis, MN USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2016年 / 375卷 / 21期

关键词：

AMYOTROPHIC-LATERAL-SCLEROSIS; QUALITY-OF-LIFE; DEVICES; CORTEX; OUTPUT; SCALE; FMRI; BCI;

D O I：

10.1056/NEJMoa1608085

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Options for people with severe paralysis who have lost the ability to communicate orally are limited. We describe a method for communication in a patient with late-stage amyotrophic lateral sclerosis (ALS), involving a fully implanted brain-computer interface that consists of subdural electrodes placed over the motor cortex and a transmitter placed subcutaneously in the left side of the thorax. By attempting to move the hand on the side opposite the implanted electrodes, the patient accurately and independently controlled a computer typing program 28 weeks after electrode placement, at the equivalent of two letters per minute. The brain-computer interface offered autonomous communication that supplemented and at times supplanted the patient's eye-tracking device. (Funded by the Government of the Netherlands and the European Union; ClinicalTrials.gov number, NCT02224469.)

引用

页码：2060 / 2066

页数：7

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