Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release

被引：66

作者：

Li, Yang ^{[1
,2
]}

Lin, Jinyan ^{[1
,2
]}

Yang, Xiangrui ^{[1
]}

Li, Yanxiu ^{[1
]}

Wu, Shichao ^{[1
]}

Huang, Yu ^{[1
]}

Ye, Shefang ^{[1
]}

Xie, Liya ^{[3
]}

Dai, Lizong ^{[1
]}

Hou, Zhenqing ^{[1
]}

机构：

[1] Xiamen Univ, Coll Mat, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Peoples R China

[3] Xiamen Univ, Affiliated Hosp 1, Xiamen 361002, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 32期

基金：

中国国家自然科学基金;

关键词：

anticancer-phospholipid complex; self-assembly; nanoparticles; targeted drug delivery; sustained/controlled drug release; FUNCTIONALIZED NANOSCALE MICELLES; PLA HYBRID NANOPARTICLES; MITOMYCIN-C; TUMOR-CELLS; THERAPEUTICS; METHOTREXATE; INHIBITORS; EFFICACY; PRODRUG;

D O I：

10.1021/acsami.5b05038

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Integrating advantages of mitomycin C (MMC)-phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC- phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in He La tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.

引用

页码：17573 / 17581

页数：9

共 28 条

[11] Efficient Delivery of Antitumor Drug to the Nuclei of Tumor Cells by Amphiphilic Biodegradable Poly(L-Aspartic Acid-co-Lactic Acid)/DPPE Co-Polymer Nanoparticles [J].

Han, Siyuan ;

Liu, Yuexian ;

Nie, Xin ;

Xu, Qing ;

Jiao, Fang ;

Li, Wei ;

Zhao, Yuliang ;

Wu, Yan ;

Chen, Chunying .

SMALL, 2012, 8 (10) :1596-1606

[12] Phytosomes Loaded with Mitomycin C-Soybean Phosphatidylcholine Complex Developed for Drug Delivery [J].

Hou, Zhenqing ;

Li, Yang ;

Huang, Yuancan ;

Zhou, Chunxiao ;

Lin, Jinyan ;

Wang, Yixiao ;

Cui, Fei ;

Zhou, Shuifan ;

Jia, Mengmeng ;

Ye, Shefang ;

Zhang, Qiqing .

MOLECULAR PHARMACEUTICS, 2013, 10 (01) :90-101

[13] METAL-COMPLEXES OF MITOMYCINS [J].

IYENGAR, BS ;

TAKAHASHI, T ;

REMERS, WA ;

BRADNER, WT .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (01) :144-147

[14] Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery [J].

Jin, Erlei ;

Zhang, Bo ;

Sun, Xuanrong ;

Zhou, Zhuxian ;

Ma, Xinpeng ;

Sun, Qihang ;

Tang, Jianbin ;

Shen, Youqing ;

Van Kirk, Edward ;

Murdoch, William J. ;

Radosz, Maciej .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (02) :933-940

[15] Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives [J].

Khan, Junaid ;

Alexander, Amit ;

Ajazuddin ;

Saraf, Swarnlata ;

Saraf, Shailendra .

JOURNAL OF CONTROLLED RELEASE, 2013, 168 (01) :50-60

[16] Orthogonally Functionalized Nanoscale Micelles for Active Targeted Code livery of Methotrexate and Mitomycin C with Synergistic Anticancer Effect [J].

Li, Yang ;

Lin, Jinyan ;

Wu, Hongjie ;

Chang, Ying ;

Yuan, Conghui ;

Liu, Cheng ;

Wang, Shuang ;

Hou, Zhenqing ;

Dai, Lizong .

MOLECULAR PHARMACEUTICS, 2015, 12 (03) :769-782

[17]

Li Y, 2014, J MATER CHEM B, V2, P6534, DOI 10.1039/c4tb00499j

[18] Mitomycin C-Soybean Phosphatidylcholine Complex-Loaded Self-Assembled PEG-Lipid-PLA Hybrid Nanoparticles for Targeted Drug Delivery and Dual-Controlled Drug Release [J].

Li, Yang ;

Wu, Hongjie ;

Yang, Xiangrui ;

Jia, Mengmeng ;

Li, Yanxiu ;

Huang, Yu ;

Lin, Jinyan ;

Wu, Shichao ;

Hou, Zhenqing .

MOLECULAR PHARMACEUTICS, 2014, 11 (08) :2915-2927

[19] Folate-Decorated and Reduction-Sensitive Micelles Assembled from Amphiphilic Polymer-Camptothecin Conjugates for Intracellular Drug Delivery [J].

Liu, Chaoyu ;

Yuan, Jiang ;

Luo, Xiaoming ;

Chen, Maohua ;

Chen, Zhoujiang ;

Zhao, Yuancong ;

Li, Xiaohong .

MOLECULAR PHARMACEUTICS, 2014, 11 (11) :4258-4269

[20] Nanocomplex Based on Biocompatible Phospholipids and Albumin for Long-Circulation Applications [J].

Peng, Qiang ;

Wei, Xue-Qin ;

Shao, Xiao-Ru ;

Zhang, Ting ;

Zhang, Shu ;

Fu, Na ;

Cai, Xiao-Xiao ;

Zhang, Zhi-Rong ;

Lin, Yun-Feng .

ACS APPLIED MATERIALS & INTERFACES, 2014, 6 (16) :13730-13737

← 1 2 3 →