Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release

被引：66

作者：

Li, Yang ^{[1
,2
]}

Lin, Jinyan ^{[1
,2
]}

Yang, Xiangrui ^{[1
]}

Li, Yanxiu ^{[1
]}

Wu, Shichao ^{[1
]}

Huang, Yu ^{[1
]}

Ye, Shefang ^{[1
]}

Xie, Liya ^{[3
]}

Dai, Lizong ^{[1
]}

Hou, Zhenqing ^{[1
]}

机构：

[1] Xiamen Univ, Coll Mat, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Peoples R China

[3] Xiamen Univ, Affiliated Hosp 1, Xiamen 361002, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 32期

基金：

中国国家自然科学基金;

关键词：

anticancer-phospholipid complex; self-assembly; nanoparticles; targeted drug delivery; sustained/controlled drug release; FUNCTIONALIZED NANOSCALE MICELLES; PLA HYBRID NANOPARTICLES; MITOMYCIN-C; TUMOR-CELLS; THERAPEUTICS; METHOTREXATE; INHIBITORS; EFFICACY; PRODRUG;

D O I：

10.1021/acsami.5b05038

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Integrating advantages of mitomycin C (MMC)-phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC- phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in He La tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.

引用

页码：17573 / 17581

页数：9

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