Clonal Evolution in Aplastic Anemia

被引：57
作者：
Afable, Manuel G., II [1 ,2 ]
Tiu, Ramon V. [1 ,2 ]
Maciejewski, Jaroslaw P. [1 ,2 ]
机构：
[1] Cleveland Clin, Taussig Canc Inst, Dept Translat Hematol & Oncol Res, Cleveland, OH 44195 USA
[2] Cleveland Clin, Taussig Canc Inst, Dept Hematol Oncol & Blood Disorders, Cleveland, OH 44195 USA
来源：
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM | 2011年
关键词：
D O I：
10.1182/asheducation-2011.1.90
中图分类号：
G40 [教育学];
学科分类号：
040101 ; 120403 ;
摘要：
Current immunosuppressive treatment (IST) induces remissions in 50%-70% of patients with aplastic anemia (AA) and result in excellent long-term survival. In recent years, the survival of refractory patients has also improved. Apart from relapse and refractoriness to IST, evolution of clonal diseases, including paroxysmal nocturnal hemoglobinuria and myelodysplastic syndrome (MDS), are the most serious long-term complications and constitute a strong argument for definitive therapy with BM transplantation if possible. Consequently, the detection of diagnostic chromosomal abnormalities (mostly monosomy 7) is of great clinical importance. Newer whole-genome scanning technologies such as single nucleotide polymorphism (SNP) array-based karyotyping may be a helpful diagnostic test for the detection of chromosomal defects in AA due to its precision/resolution and lack of reliance on cell division.
引用
收藏
页码：90 / 95
页数：6
相关论文
共 44 条
[1]   Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia [J].
Afable, Manuel G., II ;
Shaik, Mohammed ;
Sugimoto, Yuka ;
Elson, Paul ;
Clemente, Michael ;
Makishima, Hideki ;
Sekeres, Mikkael A. ;
Lichtin, Alan ;
Advani, Anjali ;
Kalaycio, Matt ;
Tiu, Ramon V. ;
O'Keefe, Christine L. ;
Maciejewski, Jaroslaw P. .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2011, 96 (09) :1269-1275
[2]   SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes [J].
Afable, Manuel G., II ;
Wlodarski, Marcin ;
Makishima, Hideki ;
Shaik, Mohammed ;
Sekeres, Mikkael A. ;
Tiu, Ramon V. ;
Kalaycio, Matt ;
O'Keefe, Christine L. ;
Maciejewski, Jaroslaw P. .
BLOOD, 2011, 117 (25) :6876-6884
[3]  
[Anonymous], 2007, HAEMATOLOGICA, V92, P11
[4]   Comparison between horse and rabbit antithymocyte globulin as first-line treatment for patients with severe aplastic anemia: a single-center retrospective study [J].
Atta, Elias Hallack ;
Saldanha, Danielle ;
Dias, Peixoto ;
Marra, Vera Lucia Neves ;
de Azevedo, Alexandre Mello .
ANNALS OF HEMATOLOGY, 2010, 89 (09) :851-859
[5]   Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients [J].
Bacigalupo, A ;
Bruno, B ;
Saracco, P ;
Di Bona, E ;
Locasciulli, A ;
Locatelli, F ;
Gabbas, A ;
Dufour, C ;
Arcese, W ;
Testi, G ;
Broccia, G ;
Carotenuto, M ;
Coser, P ;
Barbui, T ;
Leoni, P ;
Ferster, A .
BLOOD, 2000, 95 (06) :1931-1934
[6]   Guidelines for the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria and Related Disorders by Flow Cytometry [J].
Borowitz, Michael J. ;
Craig, Fiona E. ;
DiGiuseppe, Joseph A. ;
Illingworth, Andrea J. ;
Rosse, Wendell ;
Sutherland, D. Robert ;
Wittwer, Carl T. ;
Richards, Stephen J. .
CYTOMETRY PART B-CLINICAL CYTOMETRY, 2010, 78B (04) :211-228
[7]  
DEPLANQUE MM, 1989, BRIT J HAEMATOL, V73, P121
[8]   Antithymocyte globulin with or without cyclosporin A: 11-year follow-up of a randomized trial comparing treatments of aplastic anemia [J].
Frickhofen, N ;
Heimpel, H ;
Kaltwasser, JP ;
Schrezenmeier, H .
BLOOD, 2003, 101 (04) :1236-1242
[9]   Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML [J].
Gondek, Lukasz P. ;
Tiu, Ramon ;
O'Keefe, Christine L. ;
Sekeres, Mikkael A. ;
Theil, Karl S. ;
Maciejewski, Jaroslaw R. .
BLOOD, 2008, 111 (03) :1534-1542
[10]   Clinical relevance of cytogenetic abnormalities at diagnosis of acquired aplastic anaemia in adults [J].
Gupta, Vikas ;
Brooker, Carol ;
Tooze, Jennifer A. ;
Yi, Qi-long ;
Sage, Deborah ;
Turner, David ;
Kangasabapathy, Pamela ;
Marsh, Judith C. W. .
BRITISH JOURNAL OF HAEMATOLOGY, 2006, 134 (01) :95-99
12345