Interference: an alteRNAtive therapy following acute myocardial infarction

被引：8

作者：

Monaghan, Michael ^{[1
]}

Greiser, Udo ^{[2
]}

Wall, J. Gerard ^{[1
,3
]}

O'Brien, Timothy ^{[2
]}

Pandit, Abhay ^{[1
]}

机构：

[1] Natl Univ Ireland, Network Excellence Funct Biomat, Galway, Ireland

[2] Natl Univ Ireland, Regenerat Med Inst, Natl Ctr Biomed Engn Sci, Galway, Ireland

[3] Natl Univ Ireland, Sch Nat Sci, Galway, Ireland

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2012年 / 33卷 / 12期

基金：

爱尔兰科学基金会;

关键词：

gene therapy; myocardial infarction; non-viral gene delivery; ligand; siRNA; RNAi; microRNA; IMPROVES CARDIAC-FUNCTION; INFLAMMATORY RESPONSE; ENDOTHELIAL-CELLS; ANTIBODY FRAGMENT; GENE DELIVERY; HEART; MICRORNAS; HYPERTROPHY; DYSFUNCTION; IMMUNOLIPOSOMES;

D O I：

10.1016/j.tips.2012.09.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A complex cascade of genomic and proteomic interactions follows myocardial infarction (MI) irrespective of the intervention employed. A potential pharmacological intervention gaining momentum is RNAi therapy. RNAi therapy has been successfully clinically used in the treatment of age-related macular degeneration and cancer, but its translation to the coronary care unit is lacking despite the existence of preclinical proof of concept. Here we review current RNAi approaches and tissue-specific delivery systems that exhibit candidacy as future pharmacological interventions following MI and considerations for improved non-viral delivery to the infarcted myocardium.

引用

页码：635 / 645

页数：11

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