Mechanisms of cancer metastasis

被引：139

作者：

Castaneda, Maria ^{[1
]}

den Hollander, Petra ^{[2
,3
]}

Kuburich, Nick A. ^{[1
,2
,3
]}

Rosen, Jeffrey M. ^{[4
]}

Mani, Sendurai A. ^{[1
,2
,3
,5
]}

机构：

[1] MD Anderson Canc Ctr, Translat Mol Pathol, Houston, TX 77030 USA

[2] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA

[3] Brown Univ, Legoretta Canc Ctr, Providence, RI USA

[4] Baylor Coll Med, Mol & Cellular Biol, Houston, TX 77030 USA

[5] Brown Univ, Warren Alpert Med Sch, Dept Pathol & Lab Med, Providence, RI 02903 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2022年 / 87卷

关键词：

Cancer metastasis; Epithelial-mesenchymal transition; Epithelial-mesenchymal plasticity; Invasion; Extravasation; ENDOTHELIAL GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; MOUSE MODELS; TUMOR-GROWTH; STEM-CELLS; COLLECTIVE MIGRATION; E-CADHERIN; IN-VIVO; PERSONALIZED MEDICINE; IMMUNE SURVEILLANCE;

D O I：

10.1016/j.semcancer.2022.10.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from metastatic disease. Combating cancer metastasis and post-therapeutic recurrence successfully requires understanding each step of metastatic progression. This review describes the current state of knowledge of the etiology and mechanism of cancer progression from primary tumor growth to the formation of new tumors in other parts of the body. Open questions, avenues for future research, and therapeutic approaches with the potential to prevent or inhibit metastasis through personalization to each patient's mutation and/or immune profile are also highlighted.

引用

页码：17 / 31

页数：15

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