Detection of butane metabolites as an indicator of butane abuse

被引：2

作者：

Kinoshita, Hiroshi ^{[1
]}

Tanaka, Naoko ^{[1
]}

Takakura, Ayaka ^{[1
]}

Kumihashi, Mitsuru ^{[1
]}

Jamal, Mostofa ^{[1
]}

Ito, Asuka ^{[1
]}

Kimura, Shoji ^{[1
]}

Tsutsui, Kunihiko ^{[2
]}

Nagasaki, Yasushi ^{[3
]}

Matsubara, Shuji ^{[4
,5
]}

Ameno, Kiyoshi ^{[1
]}

机构：

[1] Kagawa Univ, Dept Forens Med, Fac Med, 1750-1 Ikenobe, Kita, Kagawa 7610793, Japan

[2] Kagawa Univ, Fac Med, Sch Nursing, Hlth Sci, Kita, Kagawa, Japan

[3] Hyogo Med Examiners Off, Hyogo Ku, Arata Cho, Kobe, Hyogo, Japan

[4] Kagawa Univ Hosp, Community Hlth Care Educ Support Ctr, Kita, Kagawa, Japan

[5] Kagawa Univ Hosp, Postgrad Clin Educ Ctr, Kita, Kagawa, Japan

来源：

ROMANIAN JOURNAL OF LEGAL MEDICINE | 2016年 / 24卷 / 03期

关键词：

biomarker; abuse; volatile substance; head-space solid-phase microextraction with gas chromatography-mass spectrometry (HS-SPME/GC-MS); HEADSPACE GAS-CHROMATOGRAPHY; DEATHS; SPECTROMETRY; SUBSTANCES; INHALATION;

D O I：

10.4323/rjlm.2016.216

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

We have identified 2-butanol, 2-butanone, and t-butanol with a faint peak of n-butane in a postmortem blood sample from an inhalant abuser by using head-space solid-phase microextraction coupled with gas chromatography mass spectrometry (HS-SPME/GC-MS). The compounds 2-butanol, 2-butanone, and t-butanol are metabolites of n-butane and isobutane. We concluded that the victim had abused volatile gases prior to death. The identification of metabolites of gases in the blood may be a good biomarker of volatile gas abuse.

引用

页码：216 / 218

页数：3

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